Hendriks H E, Kuster B F, Marin G B
Technische Universiteit Eindhoven, Laboratorium voor Chemische Technologie, The Netherlands.
Carbohydr Res. 1990 Sep 5;204:121-9. doi: 10.1016/0008-6215(90)84027-r.
The selective oxidation of lactose by molecular oxygen has been studied in a batch reactor containing an aqueous slurry of 0.5 kmol m-1 reactant and 1.0 kg m-3 catalyst. The in situ Bi promotion of a commercial Pd-C catalyst resulted in 100% selectivity to sodium lactobionate up to conversions of 95% in the pH range 7-10 and at temperatures up to 333 K. Performing the reaction under such conditions that the oxygen transfer to the liquid phase was rate-controlling allowed the production of sodium lactobionate in high yields in approximately 1 h. A maximum initial reaction-rate of 0.47 mol kg-1 s-1 was found at a molar Bi to Pd ratio of 0.50-0.67. Fifteen batches of lactose were oxidized with the same charge of catalyst without significant loss in initial activity or selectivity. Such other aldoses as maltose, glucose, and galactose could be oxidized analogously with similar selectivities.
在一个间歇反应器中，对含有0.5 kmol m⁻³反应物的水浆和1.0 kg m⁻³催化剂的体系进行了乳糖被分子氧选择性氧化的研究。商业Pd-C催化剂的原位铋促进作用在pH值7 - 10和温度高达333 K的条件下，直至95%的转化率时对乳糖酸钠的选择性达到100%。在氧向液相的转移为速率控制步骤的条件下进行反应，大约1小时内可高产率地生产乳糖酸钠。在铋与钯的摩尔比为0.50 - 0.67时，发现最大初始反应速率为0.47 mol kg⁻¹ s⁻¹。用相同量的催化剂对十五批乳糖进行氧化，初始活性和选择性没有明显损失。麦芽糖、葡萄糖和半乳糖等其他醛糖也可以类似地被氧化，且具有相似的选择性。
