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[关于硼替佐米促进药物透过血脑屏障的研究]

[Research of bornrol promote drugs through blood-brain barrier].

作者信息

Lv Xuxiao, Sun Mingjiang, Sun Fengzhi

机构信息

Shandong University of Traditional Chinese Medicine, Ji'nan 250355, China.

出版信息

Zhongguo Zhong Yao Za Zhi. 2012 Apr;37(7):878-81.

Abstract

Malignant tumor, epilepsy, dementia, cerebral ischemia and other brain diseases have very high rates of disability and mortality. Currently, many drugs are developed to treat such diseases and the effect is obviously. But they can not achieve the purpose to control these diseases because many of the drugs can not pass through the blood-brain barrier (BBB). Therefore, the treatment is not good. Borneol as the represent of the aromatic resuscitation medicine, it has strong fat-soluble active ingredients, small molecular weight, volatile and through the BBB quickly. It can also promote other therapeutic drugs through the BBB. It has two-ways regulations on BBB permeability and the damage of brain tissue is small, this have important theoretical significances and application values.

摘要

恶性肿瘤、癫痫、痴呆、脑缺血等脑部疾病具有很高的致残率和死亡率。目前,许多药物被开发用于治疗此类疾病,且效果明显。但由于许多药物无法通过血脑屏障(BBB),所以无法达到控制这些疾病的目的。因此,治疗效果不佳。冰片作为芳香开窍药的代表,其脂溶性活性成分强、分子量小、具挥发性且能快速通过血脑屏障。它还能促进其他治疗药物通过血脑屏障。它对血脑屏障通透性具有双向调节作用,且对脑组织损伤小,这具有重要的理论意义和应用价值。

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