用高比放射性对免疫球蛋白G进行镓标记。
Ga-labeling of immunoglobulin G with high specific radioactivity.
作者信息
Furukawa T, Fujibayashi Y, Fukunaga M, Yokoyama A
机构信息
Department of Health Chemistry, Kansai Medical University, Osaka, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1990 Aug;38(8):2285-6. doi: 10.1248/cpb.38.2285.
To obtain radiogallium labeled immunoglobulin G with a high specific radioactivity for in vitro use, a 67Ga source was purified by extraction from 67Ga-gallium citrate with butyl acetate, and a 67Ga-labeling solution was produced. This solution was then used to label a deferoxamine-immunoglobulin G conjugate. Both a very high specific radioactivity (872 +/- 56 MBq/mg) and a high labeling efficiency (94.0%) were achieved.
为获得用于体外的具有高比放射性的放射性镓标记免疫球蛋白G，通过用乙酸丁酯从柠檬酸镓-67Ga中萃取来纯化67Ga源，并制备了67Ga标记溶液。然后使用该溶液标记去铁胺-免疫球蛋白G偶联物。实现了非常高的比放射性（872±56 MBq/mg）和高标记效率（94.0%）。
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