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Identification and functional studies of a new Nrf2 partner IQGAP1: a critical role in the stability and transactivation of Nrf2.鉴定和功能研究 Nrf2 的一个新伴侣 IQGAP1：在 Nrf2 的稳定性和转录激活中起关键作用。
Antioxid Redox Signal. 2013 Jul 10;19(2):89-101. doi: 10.1089/ars.2012.4586. Epub 2012 Sep 17.
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The Ras GTPase-activating-like protein IQGAP1 mediates Nrf2 protein activation via the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)-ERK pathway.Ras GTPase 激活样蛋白 IQGAP1 通过丝裂原活化蛋白激酶/细胞外信号调节激酶（ERK）激酶（MEK）-ERK 通路介导 Nrf2 蛋白激活。
J Biol Chem. 2013 Aug 2;288(31):22378-86. doi: 10.1074/jbc.M112.444182. Epub 2013 Jun 20.
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The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains.核辅因子 RAC3/AIB1/SRC-3 通过与转录激活结构域相互作用增强 Nrf2 信号通路。
Oncogene. 2013 Jan 24;32(4):514-27. doi: 10.1038/onc.2012.59. Epub 2012 Feb 27.
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PM2.5 induces Nrf2-mediated defense mechanisms against oxidative stress by activating PIK3/AKT signaling pathway in human lung alveolar epithelial A549 cells.PM2.5 通过激活人肺肺泡上皮 A549 细胞中的 PIK3/AKT 信号通路诱导 Nrf2 介导的抗氧化应激防御机制。
Cell Biol Toxicol. 2013 Jun;29(3):143-57. doi: 10.1007/s10565-013-9242-5. Epub 2013 Mar 24.
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Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defenses.细胞核血红素加氧酶-1（HO-1）调节Nrf2的亚细胞分布和激活，影响代谢和抗氧化防御。
J Biol Chem. 2014 Sep 26;289(39):26882-26894. doi: 10.1074/jbc.M114.567685. Epub 2014 Aug 8.
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Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target.古柯二醇通过激活人乳腺上皮细胞中的 Nrf2 诱导血红素加氧酶-1 的表达：PTEN 作为一个假定的靶点。
Carcinogenesis. 2012 Feb;33(2):368-76. doi: 10.1093/carcin/bgr259. Epub 2011 Nov 17.
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Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling.白皮杉醇通过激活 ARE 驱动的 Nrf2 信号诱导人乳腺上皮细胞血红素加氧酶-1 的表达。
Arch Biochem Biophys. 2010 Sep 1;501(1):142-50. doi: 10.1016/j.abb.2010.06.011. Epub 2010 Jun 15.
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Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene.亚砷酸盐激活人血红素加氧酶-1基因转录过程中Nrf2与组蛋白H3丝氨酸10磷酸化的协同调控
Biochim Biophys Acta. 2015 Oct;1849(10):1277-88. doi: 10.1016/j.bbagrm.2015.08.004. Epub 2015 Aug 18.
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Up-down regulation of HO-1 and iNOS gene expressions by ethyl pyruvate via recruiting p300 to Nrf2 and depriving It from p65.通过募集 p300 蛋白至 Nrf2 并将其从 p65 上剥夺，1-辛烯-3-基丙酮酸乙酯对 HO-1 和 iNOS 基因表达的上调和下调调控作用。
Free Radic Biol Med. 2013 Dec;65:468-476. doi: 10.1016/j.freeradbiomed.2013.07.028. Epub 2013 Jul 24.
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Miltirone protects human EA.hy926 endothelial cells from oxidized low-density lipoprotein-derived oxidative stress via a heme oxygenase-1 and MAPK/Nrf2 dependent pathway.米利酮通过血红素氧合酶-1 和 MAPK/Nrf2 依赖途径保护人 EA.hy926 内皮细胞免受氧化型低密度脂蛋白引起的氧化应激。
Phytomedicine. 2016 Dec 15;23(14):1806-1813. doi: 10.1016/j.phymed.2016.11.003. Epub 2016 Nov 4.
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How to deal with frenemy NRF2: Targeting NRF2 for chemoprevention and cancer therapy.如何应对亦敌亦友的NRF2：靶向NRF2进行化学预防和癌症治疗。
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Activation of Nuclear Factor Erythroid 2-Related Factor-2 by Oxylipin from Leaves.叶片中氧化脂质对核因子红细胞2相关因子2的激活作用
Antioxidants (Basel). 2024 Sep 16;13(9):1119. doi: 10.3390/antiox13091119.
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Protective Effects of Relaxin 2 (RLXH2) against Hypoxia-Induced Oxidative Damage and Cell Death via Activation of The Nrf2/HO-1 Signalling Pathway in Gastric Cancer Cells.松弛素2（RLXH2）通过激活胃癌细胞中的Nrf2/HO-1信号通路对缺氧诱导的氧化损伤和细胞死亡的保护作用。
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Upregulation of IQGAP2 by EBV transactivator Rta and its influence on EBV life cycle.EBV 转录激活物 Rta 上调 IQGAP2 的表达及其对 EBV 生命周期的影响。
J Virol. 2023 Aug 31;97(8):e0054023. doi: 10.1128/jvi.00540-23. Epub 2023 Jul 28.
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Root Extract Increases Antioxidant Genes by Induction of NRF2 in HeLa Cells.根提取物通过诱导HeLa细胞中的NRF2增加抗氧化基因。
Plants (Basel). 2022 Oct 29;11(21):2914. doi: 10.3390/plants11212914.
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Medicarpin Increases Antioxidant Genes by Inducing NRF2 Transcriptional Level in HeLa Cells.美迪紫檀素通过诱导HeLa细胞中NRF2转录水平增加抗氧化基因。
Antioxidants (Basel). 2022 Feb 18;11(2):421. doi: 10.3390/antiox11020421.
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Roles of NAD and Its Metabolites Regulated Calcium Channels in Cancer.NAD 及其代谢物调节钙通道在癌症中的作用。
Molecules. 2020 Oct 20;25(20):4826. doi: 10.3390/molecules25204826.
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Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy.瞬时受体电位离子通道 TRPM2 通过调节线粒体功能、ROS 和自噬促进 AML 增殖和存活。
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The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2.人类瞬时受体电位 M 亚家族 2 离子通道通过 Nrf2 调节活性氧。
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2-Methoxy-7-Acetonyljuglone Isolated from Increases the Activity of Nuclear Factor Erythroid 2-Related Factor-2 through Inhibition of Ubiquitin Degradation in HeLa Cells.从[具体来源未给出]中分离出的2-甲氧基-7-丙酮基胡桃酮通过抑制HeLa细胞中的泛素降解来增加核因子红细胞2相关因子-2的活性。
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本文引用的文献
1
The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains.核辅因子 RAC3/AIB1/SRC-3 通过与转录激活结构域相互作用增强 Nrf2 信号通路。
Oncogene. 2013 Jan 24;32(4):514-27. doi: 10.1038/onc.2012.59. Epub 2012 Feb 27.
2
Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β.激活的小胶质细胞降低星形胶质细胞中的组蛋白乙酰化和 Nrf2 诱导的抗氧化防御：HDAC、p38 MAPK 和 GSK3β 抑制剂的恢复作用。
Neurobiol Dis. 2011 Oct;44(1):142-51. doi: 10.1016/j.nbd.2011.06.016. Epub 2011 Jul 2.
3
tBHQ-induced HO-1 expression is mediated by calcium through regulation of Nrf2 binding to enhancer and polymerase II to promoter region of HO-1.叔丁基对苯二酚诱导的 HO-1 表达是通过钙调节 Nrf2 与 HO-1 增强子和聚合酶 II 结合到启动子区域来介导的。
Chem Res Toxicol. 2011 May 16;24(5):670-6. doi: 10.1021/tx1004369. Epub 2011 Apr 5.
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KPNA6 (Importin {alpha}7)-mediated nuclear import of Keap1 represses the Nrf2-dependent antioxidant response.KPNA6（Importin α7）-介导的 Keap1 核输入抑制了 Nrf2 依赖性抗氧化反应。
Mol Cell Biol. 2011 May;31(9):1800-11. doi: 10.1128/MCB.05036-11. Epub 2011 Mar 7.
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SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.SCF/{beta}-TrCP 通过 Keap1 非依赖方式促进糖原合酶激酶 3 依赖性的 Nrf2 转录因子降解。
Mol Cell Biol. 2011 Mar;31(6):1121-33. doi: 10.1128/MCB.01204-10. Epub 2011 Jan 18.
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Regulation of the Nrf2-Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases.泛素蛋白酶体系统对 Nrf2-Keap1 抗氧化反应的调节：对环泛素连接酶的深入了解。
Antioxid Redox Signal. 2010 Dec 1;13(11):1699-712. doi: 10.1089/ars.2010.3211. Epub 2010 Aug 14.
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Regulation of NF-E2-related factor 2 signaling for cancer chemoprevention: antioxidant coupled with antiinflammatory.NF-E2 相关因子 2 信号转导在癌症化学预防中的调控：抗氧化与抗炎作用的偶联。
Antioxid Redox Signal. 2010 Dec 1;13(11):1679-98. doi: 10.1089/ars.2010.3276. Epub 2010 Aug 17.
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Neuroprotection through stimulation of mitochondrial antioxidant protein expression.通过刺激线粒体抗氧化蛋白表达实现神经保护。
J Alzheimers Dis. 2010;20 Suppl 2:S427-37. doi: 10.3233/JAD-2010-100519.
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Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway.癌症化学预防机制通过 Keap1-Nrf2 通路介导。
Antioxid Redox Signal. 2010 Dec 1;13(11):1713-48. doi: 10.1089/ars.2010.3221. Epub 2010 Aug 14.
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A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.自噬缺陷激活 Nrf2 的非经典机制：Keap1 和 p62 之间的直接相互作用。
Mol Cell Biol. 2010 Jul;30(13):3275-85. doi: 10.1128/MCB.00248-10. Epub 2010 Apr 26.
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