氟康唑成功治疗念珠菌性骨髓炎：两例患者的非对照研究

Successful treatment of Candida osteomyelitis with fluconazole. A noncomparative study of two patients.

作者信息

Sugar A M, Saunders C, Diamond R D

机构信息

Evans Memorial Department of Clinical Research, University Hospital, Boston, Massachusetts 02118.

出版信息

Diagn Microbiol Infect Dis. 1990 Nov-Dec;13(6):517-20. doi: 10.1016/0732-8893(90)90084-9.

DOI:10.1016/0732-8893(90)90084-9

PMID:2279382

Abstract

We describe two patients with osteomyelitis due to Candida spp. treated with fluconazole, a new triazole antifungal. One patient had extensive involvement of ribs and costochondral regions of the anterior chest, and the other had vertebral infection. Both were cured with courses of 10 and 14 months, with greater than or equal to 1 year of follow-up after fluconazole was discontinued. Fluconazole is an attractive agent for the treatment of Candida osteomyelitis and deserves to be studied more extensively for this indication.

摘要

我们描述了两名患有念珠菌属骨髓炎的患者，他们接受了新型三唑类抗真菌药氟康唑治疗。一名患者前胸肋骨和肋软骨区域广泛受累，另一名患者有椎体感染。两名患者均经10个月和14个月疗程治愈，停用氟康唑后随访时间均大于或等于1年。氟康唑是治疗念珠菌性骨髓炎的一种有吸引力的药物，值得针对这一适应症进行更广泛的研究。