Kazeem A A
Department of Clinical Pathology, College of Medicine, University of Lagos, Nigeria.
East Afr Med J. 1990 Jun;67(6):396-403.
Earlier workers had noted that chronic renal insufficiency accounts for 1.6% of the total medical admissions in a tertiary health institution of Nigeria. Most of cases occur among Nigerians under 40 years of age, which stimulated our interest in the present study. Using laser immunonephelometry, we quantitated the circulating immune complexes (CIC) and correlated the results with those of the routine renal biochemistry. We found a high load of CIC among all the subjects studied. These complexes were unrestricted to any particular immunoglobulin class. Higher correlation was obtained between the serum urea and the sum total of the immunoglobulin classes, suggesting that polyclonal antigens may be involved in the immunonephropathy. We observed a peculiar curvilinear trend, when a consistent rise in the serum urea was correlated with an increase, then a decline in all the Ig classes. This threshold may mark the development of immune paralysis and subsequent renal shutdown.
早期的研究人员已经注意到，在尼日利亚一家三级医疗机构中，慢性肾功能不全占总医疗入院人数的1.6%。大多数病例发生在40岁以下的尼日利亚人当中，这激发了我们对本研究的兴趣。我们使用激光免疫比浊法对循环免疫复合物（CIC）进行定量，并将结果与常规肾脏生化结果进行关联。我们发现在所有研究对象中CIC负荷都很高。这些复合物不限于任何特定的免疫球蛋白类别。血清尿素与免疫球蛋白类别的总和之间具有更高的相关性，这表明多克隆抗原可能参与了免疫性肾病。当血清尿素持续升高与所有免疫球蛋白类别先增加后下降相关联时，我们观察到一种特殊的曲线趋势。这个阈值可能标志着免疫麻痹的发展以及随后的肾衰竭。
