强直性脊柱炎中循环免疫复合物的研究。
Studies of circulating immune complexes in ankylosing spondylitis.
作者信息
Kinsella T D, Lanteigne C, Lewkonia R M, Fritzler M J
出版信息
Clin Invest Med. 1982;5(4):223-30.
Circulating immune complexes (CIC) were sought, by a fluorescent antibody immunophagocytosis (FIP) assay, in the sera of 30 patients with ankylosing spondylitis (AS), 62 with rheumatoid arthritis (RA), 27 with systemic lupus erythematosus (SLE) and 67 normal controls. Component analysis of CIC revealed significant elevations of total immunoglobulin (TIg), IgM and C3 for all patient study groups. In contrast to RA and SLE, CIC in AS sera contained significantly increased IgA and decreased IgG components. Categorization of AS patients as Grade I (mild disease) or Grade II (moderate/advanced disease) revealed no significant differences between the 2 groups in mean serum levels, component composition or prevalence of CIC. These results confirm the occurrence of CIC in AS but do not clarify the pathogenetic influence, if any, of CIC in this disease.
采用荧光抗体免疫吞噬法（FIP）检测了30例强直性脊柱炎（AS）患者、62例类风湿关节炎（RA）患者、27例系统性红斑狼疮（SLE）患者及67名正常对照者血清中的循环免疫复合物（CIC）。CIC的成分分析显示，所有患者研究组的总免疫球蛋白（TIg）、IgM和C3均显著升高。与RA和SLE不同，AS血清中的CIC含有显著增加的IgA成分和减少的IgG成分。将AS患者分为I级（轻度疾病）或II级（中度/重度疾病），两组在平均血清水平、成分组成或CIC患病率方面均无显著差异。这些结果证实了AS中存在CIC，但并未阐明CIC在该疾病中的致病影响（如有）。
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