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腹腔镜与开腹粘连松解术治疗粘连性小肠梗阻的系统评价和 Meta 分析。

Laparoscopic versus open adhesiolysis in patients with adhesive small bowel obstruction: a systematic review and meta-analysis.

机构信息

Department of Gastrointestinal and Pancreatic Surgery, the First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China 510080.

出版信息

Am J Surg. 2012 Nov;204(5):779-86. doi: 10.1016/j.amjsurg.2012.03.005. Epub 2012 Jul 12.

Abstract

BACKGROUND

The objective of this study was to evaluate whether surgical outcomes differ between laparoscopy versus the open approach for adhesive small bowel obstruction.

METHODS

PubMed, MEDLINE, Embase, and the Cochrane Library databases were electronically searched from 1985 to 2010. The study pooled the effects of outcomes of a total of 334 patients enrolled into 4 retrospective comparative studies using meta-analytic methods.

RESULTS

Laparoscopic adhesiolysis was associated with a reduced overall complication rate (odds ratio = .42, .25-.70, P < .01), prolonged ileus rate (odds ratio = .28, .10-.73, P = .01) and pulmonary complication rate (odds ratio = .20, .04-.94, P = .04) compared with the open approach. No significant differences were noted for intraoperative injury to bowel rates (odds ratio = 1.93, .76-4.89, P = .17), wound infection rates (odds ratio = .44, .17-1.12, P = .08), and mortality (odds ratio = .81, .12-5.49, P = .83).

CONCLUSIONS

Laparoscopic adhesiolysis is advantageous in most of the analyzed outcomes. Laparoscopic treatment of small bowel obstruction is recommended by experienced laparoscopic surgeons in selected patients.

摘要

背景

本研究旨在评估腹腔镜与开腹手术治疗粘连性小肠梗阻的手术效果是否存在差异。

方法

从 1985 年至 2010 年,我们对 PubMed、MEDLINE、Embase 和 Cochrane Library 数据库进行了电子检索。本研究采用荟萃分析方法,对纳入的 4 项回顾性比较研究中的 334 例患者的结局数据进行了汇总分析。

结果

与开腹手术相比,腹腔镜粘连松解术的总体并发症发生率(比值比=0.42,95%置信区间:0.25-0.70,P<0.01)、肠麻痹发生率(比值比=0.28,95%置信区间:0.10-0.73,P=0.01)和肺部并发症发生率(比值比=0.20,95%置信区间:0.04-0.94,P=0.04)较低。然而,术中肠损伤发生率(比值比=1.93,95%置信区间:0.76-4.89,P=0.17)、伤口感染发生率(比值比=0.44,95%置信区间:0.17-1.12,P=0.08)和死亡率(比值比=0.81,95%置信区间:0.12-5.49,P=0.83)差异无统计学意义。

结论

在大多数分析结果中,腹腔镜粘连松解术具有优势。在有经验的腹腔镜外科医生的指导下,腹腔镜治疗小肠梗阻在某些特定患者中是可行的。

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