Dawar Richa, Fabiano Andrew J, Qiu Jingxin, Khushalani Nikhil I
Roswell Park Cancer Institute, Buffalo, NY 14263, United States.
Clin Neurol Neurosurg. 2013 Apr;115(4):375-80. doi: 10.1016/j.clineuro.2012.06.017. Epub 2012 Jul 12.
To describe a unique case of secondary gliosarcoma (SGS) with widespread extra-cranial metastases that developed more than 5 years after the initial diagnosis of glioblastoma multiforme (GBM). This interval is the longest among the cases reported to date.
A PUBMED search using the key words "secondary gliosarcoma" and "extra-cranial metastases" was performed followed by a review of cited literature.
Including our report, we found 44 cases of SGS, of which only 5 developed extra-cranial metastases.
SGS with extra-cranial metastases is extremely rare. Of previously reported cases, the longest survival was 2 months after the diagnosis of SGS. The present case had a survival of 6.5 months. Our case highlights the importance of screening for extra-cranial metastases in SGS. The optimal treatment of SGS is not known and strategies based on GBM and sarcoma treatments have been employed with limited success. A combination of treatment modalities may extend survival as in the present report; however the prognosis remains poor.
描述一例独特的继发性胶质肉瘤（SGS）病例，该病例在多形性胶质母细胞瘤（GBM）初次诊断5年多后出现广泛的颅外转移。这一间隔时间是迄今为止报道的病例中最长的。
使用关键词“继发性胶质肉瘤”和“颅外转移”在PUBMED上进行检索，随后对引用文献进行综述。
包括我们的报告在内，我们发现了44例SGS病例，其中只有5例发生了颅外转移。
伴有颅外转移的SGS极为罕见。在先前报道的病例中，诊断出SGS后最长生存期为2个月。本病例的生存期为6.5个月。我们的病例强调了在SGS中筛查颅外转移的重要性。SGS的最佳治疗方法尚不清楚，基于GBM和肉瘤治疗的策略应用效果有限。如本报告所述，联合治疗方式可能会延长生存期；然而，预后仍然很差。
