糖化血红蛋白与糖耐量正常的亚洲印第安人颈动脉内膜中层厚度的关系。

Association of glycated hemoglobin with carotid intimal medial thickness in Asian Indians with normal glucose tolerance.

机构信息

Madras Diabetes Research Foundation and Dr. Mohan's Diabetes Specialities Centre, WHO Collaborating Centre for Non-Communicable Diseases Prevention and Control and IDF Centre of Education, Gopalapuram, Chennai 600 086, India.

出版信息

J Diabetes Complications. 2012 Nov-Dec;26(6):526-30. doi: 10.1016/j.jdiacomp.2012.06.002. Epub 2012 Jul 12.

DOI:10.1016/j.jdiacomp.2012.06.002

PMID:22795336

Abstract

AIM

To assess the association of glycated hemoglobin (HbA1c) levels with carotid intimal medial thickness (CIMT) in Asian Indians with normal glucose tolerance (NGT).

METHODS

Subjects with NGT were recruited from the Chennai Urban Rural Epidemiology Study carried out on a representative population of Chennai, South India. All subjects had fasting plasma glucose <100 mg/dl (5.6 mmol/l) and 2-h post load plasma glucose <140 mg/dl (7.8 mmol/l). HbA1c was measured using the Biorad Variant machine. CIMT was measured on the right common carotid artery using high-resolution B-mode ultrasonography.

RESULTS

The study group included 1383 NGT subjects, of whom 760 (54.9%) were women. The mean CIMT value in the 1st quartile of HbA1c (<5.2%) was 0.65 and it increased significantly to 0.73 in the last quartile of HbA1c (>5.8) (p<0.001). Regression analysis showed that HbA1c had a strong association with CIMT after adjusting for age, gender, waist circumference, systolic and diastolic blood pressure, LDL cholesterol, serum triglycerides, HOMA-IR and smoking (ß - 0.046, p=0.047).

CONCLUSION

Even among subjects with NGT, there is a significant increase in CIMT with increasing levels of HbA1c, showing the value of using HbA1c for diagnosis of glucose intolerance.

摘要

目的

评估糖化血红蛋白（HbA1c）水平与糖耐量正常的印度裔人群颈动脉内膜中层厚度（CIMT）之间的相关性。

方法

从印度南部钦奈城市农村流行病学研究中招募了糖耐量正常的受试者。所有受试者的空腹血糖<100mg/dl（5.6mmol/l），2 小时餐后血糖<140mg/dl（7.8mmol/l）。使用伯乐Variant 机器测量 HbA1c。使用高分辨率 B 型超声测量右侧颈总动脉的 CIMT。

结果

研究组包括 1383 名糖耐量正常的受试者，其中 760 名（54.9%）为女性。HbA1c 第 1 四分位数（<5.2%）的平均 CIMT 值为 0.65，而 HbA1c 最后 1 四分位数（>5.8%）的 CIMT 值显著增加至 0.73（p<0.001）。回归分析表明，在校正年龄、性别、腰围、收缩压和舒张压、LDL 胆固醇、血清甘油三酯、HOMA-IR 和吸烟等因素后，HbA1c 与 CIMT 呈强相关（β-0.046，p=0.047）。