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肥胖、2型糖尿病及非酒精性脂肪性肝病患者血浆脂联素水平及其与颈动脉内膜中层厚度的相关性

Plasma Adiponectin and Its Correlation with Carotid Intima-Media Thickness in Obesity and in Type 2 Diabetes and Nonalcoholic Fatty Liver Disease.

作者信息

Hussein Maha, Saif Aasem, Amin Mona, Khalafallah Osama, Hussien Ahmed, Aboulsoud Samar, Mousa Shrook

机构信息

Internal Medicine Department, Cairo University, Giza, Egypt.

Clinical and Chemical Pathology Department, Cairo University, Giza, Egypt.

出版信息

J Nutr Metab. 2023 Aug 31;2023:6661585. doi: 10.1155/2023/6661585. eCollection 2023.

DOI:10.1155/2023/6661585
PMID:37692464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10484655/
Abstract

METHODS AND RESULTS

The study included 200 Egyptian subjects. They were divided into four equal groups: group 1: obese patients with NAFLD and T2DM (O+/NAFLD+/DM+), group 2: nonobese patients with NAFLD and T2DM (O-/NAFLD+/DM+), group 3: obese nondiabetic patients with NAFLD (O+/NAFLD+/DM-), and group 4: nonobese healthy control subjects. Plasma adiponectin was measured using ELISA (enzyme-linked immunosorbent assay) technique. Ultrasonography was used to diagnose NAFLD. CIMT was assessed using Doppler ultrasonography. Plasma adiponectin was significantly lower and CIMT was significantly higher in O+/NAFLD+/DM+, as compared with O-/NAFLD+/DM+, O+/NAFLD+/DM-, and control subjects ( < 0.001 for all). A significant negative correlation was found between adiponectin and CIMT in obese patients with NAFLD ( < 0.05), but not in patients with NAFLD and T2DM. The significant independent predictors of CIMT were diabetes duration, BMI (body mass index), albumin/creatinine ratio, and cholesterol.

CONCLUSION

Plasma adiponectin is inversely correlated with CIMT in obese patients with NAFLD, but not in patients with NAFLD and T2DM. Hypoadiponectinemia could be a good indicator of cardiovascular risk in obese patients with NAFLD, with or without T2DM, but not in nonobese patients with NAFLD.

摘要

方法与结果

该研究纳入了200名埃及受试者。他们被分为四组，每组人数相等：第1组：患有非酒精性脂肪性肝病（NAFLD）和2型糖尿病（T2DM）的肥胖患者（O+/NAFLD+/DM+）；第2组：患有NAFLD和T2DM的非肥胖患者（O-/NAFLD+/DM+）；第3组：患有NAFLD的肥胖非糖尿病患者（O+/NAFLD+/DM-）；第4组：非肥胖健康对照受试者。采用酶联免疫吸附测定（ELISA）技术检测血浆脂联素。使用超声检查诊断NAFLD。采用多普勒超声评估颈动脉内膜中层厚度（CIMT）。与O-/NAFLD+/DM+组、O+/NAFLD+/DM-组和对照组相比，O+/NAFLD+/DM+组的血浆脂联素显著降低，CIMT显著升高（所有比较P<0.001）。在患有NAFLD的肥胖患者中，脂联素与CIMT之间存在显著负相关（P<0.05），但在患有NAFLD和T2DM的患者中未发现这种相关性。CIMT的显著独立预测因素为糖尿病病程、体重指数（BMI）、白蛋白/肌酐比值和胆固醇。

结论

在患有NAFLD的肥胖患者中，血浆脂联素与CIMT呈负相关，但在患有NAFLD和T2DM的患者中并非如此。低脂联素血症可能是患有或未患有T2DM的NAFLD肥胖患者心血管风险的良好指标，但在患有NAFLD的非肥胖患者中并非如此。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e693/10484655/676750f4af00/JNME2023-6661585.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e693/10484655/7e1078ce18da/JNME2023-6661585.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e693/10484655/676750f4af00/JNME2023-6661585.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e693/10484655/7e1078ce18da/JNME2023-6661585.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e693/10484655/676750f4af00/JNME2023-6661585.002.jpg

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