Morales-Cardona C A, Sánchez-Vanegas G
Oficina de Docencia e Investigación, Centro Dermatológico Federico Lleras Acosta Empresa Social del Estado Bogotá DC, Colombia.
Actas Dermosifiliogr. 2013 Jan;104(1):61-6. doi: 10.1016/j.ad.2012.05.004. Epub 2012 Jul 13.
Relapse rates in patients with acne after treatment with oral isotretinoin vary between 10% and 60% depending on the dosage regimen used, the length of follow-up, and the characteristics of the study population. The aim of this study was to determine the acne relapse rate within 2 years of completion of isotretinoin therapy and to identify the prognostic factors associated with relapse.
We studied a series of patients with cystic acne who had received a cumulative therapeutic dose of at least 120 mg/kg of oral isotretinoin. Data were analyzed using descriptive and analytical statistical methods. The relapse rate was expressed as the number of events divided by the amount of person-time. Factors predicting relapse were identified using multivariate Cox regression analysis.
A total of 142 patients were followed up for 24 months or until relapse occurred. The relapse rate was 15 events per 100 person-years of follow-up. The risk of relapse was twice as high among men. The protective effect of maintenance treatment with topical retinoids was 32% for each month of use. The risk of relapse was 3.5 times higher among women not receiving antiandrogen therapy.
The relapse rate in our study was high and similar to that reported in the literature, Maintenance treatment with topical retinoids in men and women and androgen treatment in women helped to prevent relapse.
口服异维A酸治疗痤疮患者后的复发率在10%至60%之间，具体取决于所用的剂量方案、随访时间长短以及研究人群的特征。本研究的目的是确定异维A酸治疗结束后2年内痤疮的复发率，并确定与复发相关的预后因素。
我们研究了一系列接受累积治疗剂量至少为120mg/kg口服异维A酸的囊肿性痤疮患者。使用描述性和分析性统计方法对数据进行分析。复发率表示为事件数除以人时数。使用多变量Cox回归分析确定预测复发的因素。
共对142例患者进行了24个月的随访或直至复发。复发率为每100人年随访中有15例复发事件。男性复发风险是女性的两倍。外用维甲酸维持治疗每月的保护作用为32%。未接受抗雄激素治疗的女性复发风险高3.5倍。
我们研究中的复发率较高，与文献报道相似，男性和女性外用维甲酸维持治疗以及女性雄激素治疗有助于预防复发。
