Department of Dermatology-Oncology, Hôtel-Dieu, Nantes University Hospital Centre, Nantes, France.
DATA CHAMP', Lyon, France.
J Eur Acad Dermatol Venereol. 2019 May;33(5):937-943. doi: 10.1111/jdv.15419. Epub 2019 Feb 22.
Acne is a common skin disease that mostly affects teenagers, with a negative impact on quality of life. Recently, adult acne and acne relapses have increased in frequency, for yet unknown reasons.
This non-interventional, real-life study sought to investigate the rate of acne relapses and their impact on quality of life and productivity (loss/absenteeism) among teenagers and adults.
An online self-administered questionnaire was proposed to ≥15-year-olds suffering from acne who spontaneously consulted their dermatologist. To ensure homogeneous assessment of acne severity, the global acne severity scale was applied. Quality of life was assessed via Cardiff Acne Disability Index (CADI), SF12-physical score and SF12-mental score questionnaires. Productivity loss or absenteeism in middle/high school was estimated based on the number of days off work or school over the last 30 days.
Overall, 1048 questionnaires were considered assessable, with 448 (43%) mild acne, 434 (41%) moderate acne and 166 (16%) severe acne. Overall, 755 (72%) participants were in middle/high school, 267 (25%) employed and 26 (3%) with no professional activity. Considering the population by age groups, 68% (n = 716) were ≤20-year-olds and 32% (n = 332) >20-year-olds, with a mean age of 20.26 (SD: 7.43) years. Acne relapses were reported by 44% of respondents. Analyses revealed that poorer quality of life scores was observed in acne relapsers vs. non-relapsers, with a significant difference for CADI scores (P < 0.01) in >20-year-olds. Acne-related absenteeism was recorded in 5.7% of cases. On multivariate analyses, after adjusting for other variables, acne relapse was proven a significant determinant of absenteeism/productivity loss.
This real-life study first demonstrated acne relapse rates of 44%, which appeared to be generation-dependent, affecting 39.9% of ≤20-year-olds vs. 53.3% of >20-year-olds. Acne relapses were significantly associated with impaired quality of life and productivity loss/absenteeism.
痤疮是一种常见的皮肤病，主要影响青少年，对生活质量有负面影响。最近，成人痤疮和痤疮复发的频率增加，原因尚不清楚。
本非干预性、真实世界研究旨在调查青少年和成年人痤疮复发的发生率及其对生活质量和生产力（损失/旷工）的影响。
向≥ 15 岁的痤疮患者提出在线自我管理问卷，他们会自发咨询皮肤科医生。为了确保痤疮严重程度的同质评估，应用全球痤疮严重程度量表。通过 Cardiff 痤疮残疾指数 (CADI)、SF12-生理评分和 SF12-心理评分问卷评估生活质量。根据过去 30 天的缺勤天数，估计中学/高中的生产力损失或旷工情况。
总体而言，考虑到可评估的问卷为 1048 份，其中 448 份（43%）为轻度痤疮，434 份（41%）为中度痤疮，166 份（16%）为重度痤疮。总体而言，755 名（72%）参与者在中学/高中，267 名（25%）就业，26 名（3%）无职业活动。按年龄组考虑人口，68%（n = 716）为≤20 岁，32%（n = 332）为>20 岁，平均年龄为 20.26（SD：7.43）岁。44%的受访者报告有痤疮复发。分析表明，与无复发者相比，生活质量评分较差的患者有痤疮复发，在>20 岁者中 CADI 评分差异有统计学意义（P < 0.01）。记录到与痤疮相关的旷工 5.7%。在多变量分析中，调整其他变量后，痤疮复发被证明是旷工/生产力损失的一个显著决定因素。
本真实世界研究首次证明痤疮复发率为 44%，且似乎与年龄有关，在≤20 岁者中为 39.9%，在>20 岁者中为 53.3%。痤疮复发与生活质量受损和生产力损失/旷工显著相关。
