University of Split School of Medicine and University Hospital, Split, Croatia.
J Clin Virol. 2012 Sep;55(1):4-7. doi: 10.1016/j.jcv.2012.06.006. Epub 2012 Jul 12.
Phleboviruses are large and widespread group of viruses that are transmitted by arthropods and they have been reported to circulate in endemic regions of Mediterranean Basin, including Croatia.
To investigate the role of Toscana virus, as a cause of the aseptic meningitis, in summer months in Croatia.
Samples from 30 patients with aseptic meningitis were retrospectively tested by serology and RT-PCR for TOSV.
TOSV RNA was detected in 2/30 and TOSV IgM antibodies were found in 4/30 of patients. Phylogenetic analysis of partial L and S segments suggests that TOSV from Croatia represents an autochthonous strain.
The study has confirmed the role of TOSV as an agent that causes aseptic meningitis in Croatia, therefore it should be considered by physicians when encountering meningitis or febrile illness among indigenous population or travellers during the summer months.
沙粒病毒是一种由节肢动物传播的大型且广泛分布的病毒，已在包括克罗地亚在内的地中海盆地的地方性流行区域中发现其循环存在。
调查托斯卡纳病毒（Toscana virus，TOSV）作为克罗地亚夏季无菌性脑膜炎病因的作用。
通过血清学和 RT-PCR 对 30 例无菌性脑膜炎患者的样本进行回顾性检测，以检测 TOSV。
在 30 例患者中，有 2 例检测到 TOSV RNA，4 例患者中检测到 TOSV IgM 抗体。L 和 S 节段的部分序列的系统进化分析表明，来自克罗地亚的 TOSV 代表一种本地株。
该研究证实了 TOSV 在克罗地亚引发无菌性脑膜炎的作用，因此在夏季，当遇到当地人群或旅行者的脑膜炎或发热性疾病时，医生应考虑到这一点。
