National University of Rwanda, University Teaching Hospital of Kigali, Kigali, Rwanda.
Int J Gynaecol Obstet. 2012 Oct;119(1):66-9. doi: 10.1016/j.ijgo.2012.04.024. Epub 2012 Jul 12.
To measure maternal and fetal hemodynamics during acute malaria in pregnancy.
Time courses of maternal heart rate (MHR), maternal blood pressure (BP), and fetal heart rate (FHR) were performed until 56 days after initiation of anti-malarial treatment with artemether-lumefantrine. Women with malaria were hospitalized for at least 3 days until recovery.
Mean baseline characteristics of pregnant women with malaria (n=38) versus pregnant women without malaria (n=39) were as follows: gestational age (28.8 vs 24.6 weeks; P=0.006); maximum FHR (165.3 vs 158.3 beats per minute [bpm]; P=0.054); minimum FHR (137.6 vs 128.7 bpm; P=0.016); mean BP (74.7 vs 80.9 mm Hg; P=0.001); pulse pressure (40.3 vs 42.1mm Hg; P=0.300); and MHR (107.4 vs 81.3 bpm; P<0.001). The geometric mean parasite count was 13 795 per μL. Complete time courses were collected from a subgroup of participants. For women with malaria, maternal body temperature and BP normalized within 24 hours and after 72 hours, respectively. The MHR among pregnant women without malaria showed a physiologic increase during pregnancy of approximately 7 bpm between days 0 and 56. The mean FHR among women with malaria normalized after 72 hours.
Acute malaria induces maternal and fetal hemodynamic changes.
测量妊娠合并急性疟疾期间的母婴血液动力学。
在使用青蒿琥酯-咯萘啶抗疟治疗开始后，直至治疗开始后的 56 天，对母亲的心率（MHR）、母亲的血压（BP）和胎儿的心率（FHR）进行时间进程测量。患有疟疾的妇女住院至少 3 天，直到康复。
患有疟疾的孕妇（n=38）与未患疟疾的孕妇（n=39）的基线特征平均值如下：妊娠周数（28.8 对 24.6 周；P=0.006）；最大 FHR（165.3 对 158.3 次/分钟[bpm]；P=0.054）；最小 FHR（137.6 对 128.7 bpm；P=0.016）；平均 BP（74.7 对 80.9mmHg；P=0.001）；脉压（40.3 对 42.1mm Hg；P=0.300）；和 MHR（107.4 对 81.3 bpm；P<0.001）。几何均数寄生虫计数为 13795 每μL。从参与者的一个亚组中收集了完整的时间进程。对于患有疟疾的妇女，体温和血压分别在 24 小时内和 72 小时内恢复正常。未患疟疾的孕妇的 MHR 在妊娠期间的第 0 天至第 56 天之间生理性增加了约 7bpm。患有疟疾的女性的平均 FHR 在 72 小时后恢复正常。
急性疟疾引起母婴血液动力学变化。
