晚期癌症患者、癌症幸存者和一般人群的疲劳体验差异。

Differences in fatigue experiences among patients with advanced cancer, cancer survivors, and the general population.

机构信息

Department of Medical Oncology, Erasmus MC-Daniel den Hoed Cancer Centre, Rotterdam, The Netherlands.

出版信息

J Pain Symptom Manage. 2012 Dec;44(6):823-30. doi: 10.1016/j.jpainsymman.2011.12.279. Epub 2012 Jul 13.

DOI:10.1016/j.jpainsymman.2011.12.279

PMID:22795903

Abstract

CONTEXT

Fatigue is a multidimensional symptom experienced physically, cognitively, and emotionally. Research on fatigue experiences in various stages of cancer might help to elucidate the nature of cancer-related fatigue.

OBJECTIVES

To compare fatigue experiences in advanced cancer patients (ACPs), cancer survivors (CSs), and controls from the general population (GenPop).

METHODS

Sixty-three ACPs (no antitumor therapy in the last month and no options for future therapy) were matched for age, sex and diagnosis with 63 CSs (last treatment one to five years ago) and 315 controls. Fatigue was measured unidimensionally with the Numeric Rating Scale and multidimensionally with the Multidimensional Fatigue Inventory.

RESULTS

All fatigue levels (general fatigue, physical fatigue, reduced activity, reduced motivation, and mental fatigue) were higher in ACPs than in CSs and controls (P<0.01), whereas fatigue levels were not different between CSs and controls. NRS scores in ACPs and CSs were significantly predicted by the fatigue dimensions physical fatigue and mental fatigue only. Although physical fatigue and mental fatigue were strongly related in the GenPop, the relation was weaker in CSs and not significant in ACPs. In multivariate analyses, only physical fatigue differentiated ACPs from CSs and controls (P<0.01).

CONCLUSION

ACPs experience fatigue more intensely than CSs and controls when fatigue is measured multidimensionally. Although mental and physical dimensions of fatigue contribute to the overall experience of fatigue in both groups of cancer patients, physical fatigue best differentiated ACPs from both CSs and controls.

摘要

背景

疲劳是一种身体、认知和情感多维度的症状。研究癌症各阶段的疲劳体验可能有助于阐明癌症相关性疲劳的本质。

目的

比较晚期癌症患者（ACP）、癌症幸存者（CS）和一般人群（GenPop）对照者的疲劳体验。

方法

将 63 例 ACP（最近一个月未接受抗肿瘤治疗，且未来无治疗选择）按年龄、性别和诊断与 63 例 CS（最后一次治疗 1 至 5 年前）和 315 例对照者进行匹配。使用数字评定量表（NRS）进行一维疲劳评估，使用多维疲劳量表（MFI）进行多维疲劳评估。

结果

所有疲劳水平（一般疲劳、身体疲劳、活动减少、动力降低和精神疲劳）在 ACP 中均高于 CS 和对照者（P<0.01），而 CS 和对照者之间的疲劳水平无差异。ACP 和 CS 中的 NRS 评分仅由疲劳维度身体疲劳和精神疲劳显著预测。尽管身体疲劳和精神疲劳在 GenPop 中具有很强的相关性，但在 CS 中相关性较弱，在 ACP 中不显著。多变量分析显示，仅身体疲劳能将 ACP 与 CS 和对照者区分开来（P<0.01）。