Alvarenga Kátia F, Amorim Raquel Beltrão, Agostinho-Pesse Raquel Sampaio, Costa Orozimbo Alves, Nascimento Leandra Tabanez, Bevilacqua Maria Cecilia
Department of Audiology and Speech Pathology at the School of Dentistry, University of São Paulo, Bauru Campus, Brazil.
Int J Pediatr Otorhinolaryngol. 2012 Sep;76(9):1332-8. doi: 10.1016/j.ijporl.2012.06.001. Epub 2012 Jul 15.
To characterize the P(1) component of long latency auditory evoked potentials (LLAEPs) in cochlear implant users with auditory neuropathy spectrum disorder (ANSD) and determine firstly whether they correlate with speech perception performance and secondly whether they correlate with other variables related to cochlear implant use.
This study was conducted at the Center for Audiological Research at the University of São Paulo. The sample included 14 pediatric (4-11 years of age) cochlear implant users with ANSD, of both sexes, with profound prelingual hearing loss. Patients with hypoplasia or agenesis of the auditory nerve were excluded from the study. LLAEPs produced in response to speech stimuli were recorded using a Smart EP USB Jr. system. The subjects' speech perception was evaluated using tests 5 and 6 of the Glendonald Auditory Screening Procedure (GASP).
The P(1) component was detected in 12/14 (85.7%) children with ANSD. Latency of the P(1) component correlated with duration of sensorial hearing deprivation (*p=0.007, r=0.7278), but not with duration of cochlear implant use. An analysis of groups assigned according to GASP performance (k-means clustering) revealed that aspects of prior central auditory system development reflected in the P(1) component are related to behavioral auditory skills.
In children with ANSD using cochlear implants, the P(1) component can serve as a marker of central auditory cortical development and a predictor of the implanted child's speech perception performance.
对患有听觉神经病谱系障碍（ANSD）的人工耳蜗使用者的长潜伏期听觉诱发电位（LLAEPs）的P(1)成分进行特征描述，并首先确定它们是否与言语感知表现相关，其次确定它们是否与人工耳蜗使用的其他变量相关。
本研究在圣保罗大学听觉研究中心进行。样本包括14名患有ANSD的儿科（4 - 11岁）人工耳蜗使用者，男女皆有，患有严重的语前听力损失。听觉神经发育不全或缺失的患者被排除在研究之外。使用Smart EP USB Jr.系统记录对言语刺激产生的LLAEPs。使用格伦多纳德听觉筛查程序（GASP）的测试5和测试6评估受试者的言语感知。
在14名患有ANSD的儿童中，有12名（85.7%）检测到了P(1)成分。P(1)成分的潜伏期与感觉性听力剥夺的持续时间相关（*p = 0.007，r = 0.7278），但与人工耳蜗使用的持续时间无关。根据GASP表现分组（k均值聚类）分析显示，P(1)成分所反映的先前中枢听觉系统发育方面与行为听觉技能相关。
在使用人工耳蜗的ANSD儿童中，P(1)成分可作为中枢听觉皮层发育的标志物以及植入儿童言语感知表现的预测指标。
