Rheumatology Department, Saint Lucas Hospital, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
Autoimmun Rev. 2012 Dec;12(2):230-4. doi: 10.1016/j.autrev.2012.07.008. Epub 2012 Jul 13.
The antiphospholipid syndrome (APS) is an acquired disorder characterized by arterial and/or venous thrombosis and pregnancy morbidity. In solid assays, sera from patients with APS usually react to negatively charged phospholipids (PL) and PL cofactors such as β2-glycoprotein I (β2GPI). Binding to neutral PL such as phosphatidylethanolamine (PE) is less common. PE is one of the main lipid components of the biological membranes, being mostly located in the inner leaflet. In 1989 we reported the first case of primary APS whereby a LA was accompanied not by an anticardiolipin antibody (aCL), but by an antibody to PE (aPE). In this review, we update the literature concerning the presence of aPE in patients with thromboembolic events and obstetric morbidity. We also discuss aPE as the sole antibody detected in many of these clinical circumstances. An eventual link of aPE antibodies with failure of in vitro fertilization is also considered as well as uncommon clinical associations of aPE that are also discussed.
抗磷脂综合征（APS）是一种获得性疾病，其特征为动脉和/或静脉血栓形成以及妊娠并发症。在固相检测中，APS 患者的血清通常会与带负电荷的磷脂（PL）和 PL 辅助因子如β2-糖蛋白 I（β2GPI）发生反应。与中性 PL 如磷脂酰乙醇胺（PE）的结合则较为少见。PE 是生物膜的主要脂质成分之一，主要位于内膜层。1989 年，我们报道了首例原发性 APS 病例，该病例中的 LA 并未伴随抗心磷脂抗体（aCL），而是伴随抗 PE 抗体（aPE）。在这篇综述中，我们更新了有关在血栓栓塞事件和产科并发症患者中存在 aPE 的文献。我们还讨论了 aPE 作为许多此类临床情况下唯一检测到的抗体。我们还考虑了 aPE 抗体与体外受精失败之间的潜在联系，以及 aPE 的一些不常见的临床关联，也对其进行了讨论。
