Caraiola Simona, Voicu Laura, Jurcut Ciprian, Dima Alina, Baicus Cristian, Baicus Anda, Cobilinschi Claudia Oana, Ionescu Razvan Adrian
Fifth Department-Internal Medicine (Cardiology, Gastroenterology, Hepatology, Rheumatology, Geriatrics), Family Medicine, Occupational Medicine, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Internal Medicine Department, Colentina Clinical Hospital, 020125 Bucharest, Romania.
Biomedicines. 2023 Aug 3;11(8):2192. doi: 10.3390/biomedicines11082192.
The place of non-criteria antiphospholipid antibodies (aPLs) in the diagnosis of antiphospholipid syndrome (APS) is still debatable. The aim of this research was to evaluate the correlations between the titres of non-criteria aPLs (anti-phosphatidylethanolamine (aPE), anti-phosphatidylserine (aPS), and anti-prothrombin (aPT) antibodies), and the ones of the already studied criteria aPLs (anti-cardiolipin (aCL) and anti-β2 glycoprotein I-aβ2GPI antibodies). Altogether, 72 APS (30 primary and 42 secondary) patients were included in our study. High correlation coefficients (rs) were found between aPS IgM and aCL IgM, overall (0.77, < 0.01), as well as in the primary (0.81, < 0.01), and secondary (0.75, < 0.01) APS subgroups. Low or statistically insignificant correlations were observed between IgG/IgM isotypes of aPT and aCL, or aβ2GPI, in the entire study population, and when evaluating the subgroups. Therefore, moderate correlations were mainly identified between the tested non-criteria antibodies and the criteria ones, suggesting little added value for the use of the tested non-criteria aPLs, with the exception of aPT, which seems to have different kinetics and might be a promising APS diagnostic tool.
非标准抗磷脂抗体（aPLs）在抗磷脂综合征（APS）诊断中的地位仍存在争议。本研究的目的是评估非标准aPLs（抗磷脂酰乙醇胺（aPE）、抗磷脂酰丝氨酸（aPS）和抗凝血酶原（aPT）抗体）的滴度与已研究的标准aPLs（抗心磷脂（aCL）和抗β2糖蛋白I-aβ2GPI抗体）滴度之间的相关性。本研究共纳入72例APS患者（30例原发性和42例继发性）。总体上，aPS IgM与aCL IgM之间发现高相关系数（rs）（0.77，<0.01），在原发性APS亚组（0.81，<0.01）和继发性APS亚组（0.75，<0.01）中也是如此。在整个研究人群中以及评估亚组时，观察到aPT与aCL或aβ2GPI的IgG/IgM同种型之间存在低相关性或无统计学意义的相关性。因此，在测试的非标准抗体与标准抗体之间主要发现了中等相关性，这表明除aPT外，测试的非标准aPLs的使用价值不大，aPT似乎具有不同的动力学，可能是一种有前景的APS诊断工具。
