中国农村地区既往献血人群丙型肝炎的流行状况及危险因素。

Prevalence and risk factors of hepatitis C among former blood donors in rural China.

机构信息

Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

出版信息

Int J Infect Dis. 2012 Oct;16(10):e731-4. doi: 10.1016/j.ijid.2012.05.1035. Epub 2012 Jul 15.

DOI:10.1016/j.ijid.2012.05.1035

PMID:22796320

Abstract

BACKGROUND

Illegal commercial plasma and blood donation activities in the late 1980s and early 1990s caused a large number of hepatitis C virus (HCV) infections in rural areas of China.

METHODS

A cross-sectional survey was carried out in 2008, in which all residents in a former blood donation village in rural Hebei Province were invited for a questionnaire interview and testing for HCV antibodies. Questionnaires were administered to collect information about their personal status and commercial blood donation history, and HCV antibodies were tested by enzyme immunoassay.

RESULTS

Of 520 villagers who participated in the interviews, 236 (45.4%) reported a history of selling whole blood or plasma. HCV seropositivity was confirmed in 148/520 (28.5%) interviewees and 101/236 (42.8%) former commercial plasma and blood donors. Selling plasma was the strongest independent predictor of HCV seropositivity (p=0.0037). Past history of an operation was also independently associated with HCV infection (p=0.0270).

CONCLUSIONS

Unsafe practices during illegal plasma donation led to a high risk of HCV seropositivity for donors during the late 1980s and early 1990s. Many infected people suffered chronic hepatitis from that time onwards and urgently needed treatment and care.

摘要

背景

20 世纪 80 年代末至 90 年代初，非法商业性血浆和卖血活动在中国农村地区导致了大量丙型肝炎病毒（HCV）感染。

方法

2008 年进行了一项横断面调查，邀请河北省一个原卖血村的所有居民进行问卷调查和 HCV 抗体检测。问卷调查收集个人状况和商业性卖血史信息，采用酶联免疫吸附试验检测 HCV 抗体。

结果

520 名接受访谈的村民中，236 名（45.4%）报告有卖全血或血浆的经历。520 名受访者中 148 名（28.5%）和 236 名曾有商业性卖血经历的人中 101 名（42.8%）HCV 抗体阳性。卖血浆是 HCV 抗体阳性的最强独立预测因素（p=0.0037）。既往手术史也与 HCV 感染独立相关（p=0.0270）。