Laboratoire Dynamique du Langage, CNRS UMR 5596, Lyon, France.
Epilepsy Behav. 2012 Sep;25(1):81-91. doi: 10.1016/j.yebeh.2012.05.025. Epub 2012 Jul 15.
We assessed voluntary orientation and reorientation of visuospatial attention in 313 healthy 6- to 22-year-old participants, 30 children suffering from benign epilepsy with centrotemporal spikes (BECTS) and 13 children with Panayiotopoulos syndrome (PS). The developmental section highlights the late development of reorienting skills. Only children with BECTS-R showed a strong tendency toward a rightward bias in attentional orientation. Additionally, a unilateral deficit of disengagement characterizes the patients with BECTS-R and comorbid ADHD. Right rolandic spikes seem to aggravate subclinical reorienting difficulties. Finally, children with PS failed to diffuse inhibition, except in the nearest area outside the attentional focus. This deficit could be attributed to the typical occipital-to-frontal spreading of the spikes in PS. By showing distinct attentional deficiencies according to the epileptic syndrome and the epileptic focus lateralization in BECTS, the results provide new evidence for alterations of attentional mechanisms by interictal epileptic activity, which probably contribute to learning difficulties.
我们评估了 313 名 6 至 22 岁健康参与者、30 名良性癫痫伴中央颞区棘波（BECTS）患儿和 13 名 Panayiotopoulos 综合征（PS）患儿的视空间注意力的自主定向和重新定向。发育部分强调了重新定向技能的后期发展。只有 BECTS-R 患儿表现出注意力定向的强烈右偏趋势。此外，BECTS-R 患儿合并 ADHD 存在单侧注意力脱离缺陷。右侧 Rolandic 棘波似乎加重了亚临床重新定向困难。最后，PS 患儿除了在注意力焦点的最近区域外，无法扩散抑制。这种缺陷可能归因于 PS 中棘波典型的枕部到额部传播。通过根据癫痫综合征和 BECTS 中的癫痫灶侧化表现出不同的注意力缺陷，这些结果为癫痫发作间期活动引起的注意力机制改变提供了新的证据，这可能导致学习困难。
