脂质纳米粒用于紫杉烷类药物递送的评价。
A critical review of lipid-based nanoparticles for taxane delivery.
机构信息
Center for Nanotechnology in Drug Delivery, Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
Cancer Lett. 2013 Jul 1;334(2):157-75. doi: 10.1016/j.canlet.2012.07.006. Epub 2012 Jul 13.
Abstract
Nano-based delivery systems have attracted a great deal of attention in the past two decades as a strategy to overcome the low therapeutic index of conventional anticancer drugs and delivery barriers in solid tumors. Myriads of preclinical studies have been focused on developing nano-based formulations to effectively deliver taxanes, one of the most important and most prescribed anticancer drug types in the clinic. Given the hydrophobic property of taxanes, lipid-based NPs, serve as a viable alternative delivery system. This critical review will provide an overview and perspective of the advancement of lipid-based nanoparticles for taxane delivery. Currently available formulations of taxanes and their drawbacks as well as criteria for idea taxane delivery system will be discussed.
摘要
在过去的二十年中，纳米载体给药系统作为克服传统抗癌药物治疗指数低和实体瘤递药屏障的策略受到了极大关注。大量的临床前研究致力于开发纳米制剂，以有效递紫杉醇，这是临床中最重要和最常开的抗癌药物之一。鉴于紫杉醇的疏水性，基于脂质的 NPs 是一种可行的替代递药系统。本综述将概述和讨论用于紫杉醇递药的基于脂质的纳米粒的最新进展。目前紫杉醇的制剂及其缺点以及理想的紫杉醇递药系统的标准将进行讨论。
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