Sawant Rupa R, Torchilin Vladimir P
Department of Pharmaceutical Sciences and Center for Pharmaceutical Biotechnology and Nanomedicine, Northeastern University, Boston, Massachusetts 02115, USA.
Mol Membr Biol. 2010 Oct;27(7):232-46. doi: 10.3109/09687688.2010.516276. Epub 2010 Oct 7.
Phospholipid micelles have proven to be the versatile pharmaceutical nanocarrier of choice for the delivery of poorly soluble chemotherapeutics for cancer therapy using various treatment modalities. Phospholipid micelles are typically expected to increase the accumulation of the loaded drugs in tumour tissues by taking advantage of the enhanced permeability and retention effect and by ligand-mediated active targeting. Furthermore, by tailoring the composition of the micelles, it is possible to enhance the intracellular delivery of the cargo. This review highlights the important advancements in our laboratory with polyethyleneglycol phosphatidylethanolamine (PEG-PE)-based micellar drug delivery systems for improvement of the therapeutic efficacy of poorly soluble anticancer drugs.
磷脂胶束已被证明是一种多功能的药物纳米载体，可用于通过各种治疗方式递送难溶性化疗药物以进行癌症治疗。通常期望磷脂胶束通过利用增强的通透性和滞留效应以及配体介导的主动靶向作用来增加负载药物在肿瘤组织中的积累。此外，通过调整胶束的组成，可以增强货物的细胞内递送。本综述重点介绍了我们实验室在基于聚乙二醇磷脂酰乙醇胺（PEG-PE）的胶束药物递送系统方面取得的重要进展，以提高难溶性抗癌药物的治疗效果。
