Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse, Treatment and Research, Tel Aviv, Israel.
Psychopathology. 2012;45(5):327-33. doi: 10.1159/000336219. Epub 2012 Jul 12.
The aim of this study was to evaluate the prevalence of childhood and adulthood attention deficit hyperactivity disorder (ADHD) and clinical obsessive-compulsive disorder (OCD) among adult patients in methadone maintenance treatment (MMT) and to characterize possible risk factors.
A random sample of 154 current MMT patients was studied for childhood ADHD (Wender Utah Rating Scale), current clinical OCD (Yale-Brown Obsessive Compulsive Scale), lifetime trauma history and modified Addiction Severity Index for demographics, as well as any lifetime DSM-IV-TR psychiatric diagnosis.
Fifty-one patients (33.1%) had childhood ADHD, and more of this group currently had clinical OCD compared to patients who did not have childhood ADHD (55.3 vs. 30.1%). The two groups did not differ with regard to gender and age of admission to MMT. Logistic regression found that the childhood ADHD group had a higher risk of having OCD [odds ratio (OR) 3.8, 95% confidence interval (CI) 1.6-8.8], more severe nicotine smoking (OR 1.4, 95% CI 1.1-1.7) and fewer years of education (OR 0.8, 95% CI 0.6-1) and were more likely to have a DSM-IV-TR axis II disorder (OR 4.3, 95% CI 1.4-13.4) and a history of falls (OR 4.3, 95% CI 1.4-12.9).
Although ADHD is more prevalent among males in the general population, the rates in our MMT population were similar in each gender. One third of our sample had suffered from ADHD during childhood, which may have led them to self-medicate with drugs and thus to addiction. Childhood ADHD was associated with current OCD, and both conditions were highly prevalent among our MMT patients. The reason for a history of repeated falls warrants further study.
本研究旨在评估儿童期和成年期注意缺陷多动障碍(ADHD)和成年阿片类药物维持治疗(MMT)患者中临床强迫症(OCD)的患病率,并分析可能的危险因素。
对 154 名接受 MMT 的当前患者进行了随机抽样,以评估其儿童期 ADHD(Wender Utah 评定量表)、当前临床 OCD(耶鲁-布朗强迫症量表)、终生创伤史和改良成瘾严重程度指数(用于人口统计学),以及任何终生 DSM-IV-TR 精神科诊断。
51 名患者(33.1%)存在儿童期 ADHD,该组目前临床 OCD 的发生率高于无儿童期 ADHD 的患者(55.3%比 30.1%)。两组在性别和进入 MMT 的年龄方面没有差异。Logistic 回归发现,有儿童期 ADHD 组的 OCD 风险更高[比值比(OR)3.8,95%置信区间(CI)1.6-8.8],尼古丁吸烟更严重(OR 1.4,95% CI 1.1-1.7),受教育年限更少(OR 0.8,95% CI 0.6-1),且更有可能存在 DSM-IV-TR 轴 II 障碍(OR 4.3,95% CI 1.4-13.4)和跌倒史(OR 4.3,95% CI 1.4-12.9)。
尽管 ADHD 在普通人群中男性更为常见,但我们 MMT 人群中的发生率在两性之间相似。我们的样本中有三分之一在儿童时期曾患有 ADHD,这可能导致他们用药物自我治疗,从而导致成瘾。儿童期 ADHD 与当前 OCD 相关,且这两种疾病在我们的 MMT 患者中均高度流行。反复跌倒的原因值得进一步研究。