Department of Respiratory Medicine, Kobe City Medical Center, General Hospital, Kobe, Japan.
Department of Respiratory Medicine, Kobe City Medical Center, General Hospital, Kobe, Japan.
Chest. 2012 Jul;142(1):228-230. doi: 10.1378/chest.11-1858.
The 2008 American Thoracic Society Project concluded that idiopathic nonspecific interstitial pneumonia (NSIP), once regarded as a "provisional" diagnosis, can be considered a distinct clinical entity. However, an increasing number of recent reports have shown a likely link between the entity of idiopathic NSIP and autoimmune diseases. Similarly, IgG4-related disease is being increasingly reported, and some of the lung lesions, at least radiologically, look like NSIP. A case of IgG4-related interstitial lung disease without other systemic manifestations of IgG4-related disease is reported. The existence of IgG4-related disease should, therefore, be taken into consideration as a possible differential diagnosis from NSIP. The cause of IgG4-related disease remains unknown, but we emphasize the importance of a clinically novel interstitial lung disease.
2008 年美国胸科学会的项目得出结论，特发性非特异性间质性肺炎（NSIP），曾经被视为“临时性”诊断，可以被认为是一种独特的临床实体。然而，越来越多的最近报告表明，特发性 NSIP 实体与自身免疫性疾病之间可能存在联系。同样，IgG4 相关疾病的报告也越来越多，并且一些肺部病变，至少在影像学上，看起来像 NSIP。报告了一例无 IgG4 相关疾病其他系统表现的 IgG4 相关间质性肺疾病。因此，应将 IgG4 相关疾病的存在视为 NSIP 的可能鉴别诊断。IgG4 相关疾病的病因尚不清楚，但我们强调临床新型间质性肺疾病的重要性。
