卡托普利对大鼠的一些行为影响。

Some behavioural effects of captopril in rats.

Braszko J J, Wiśniewski K

Department of Pharmacology, Medical Academy, Białystok, Poland.

Gen Pharmacol. 1990;21(6):851-7. doi: 10.1016/0306-3623(90)90444-q.

Abstract

Effects of inhibition of angiotensin converting enzyme (ACE, EC 3.4.15.1) in brain on psychomotor, exploratory, stereotyped and cognitive behaviour in rats were investigated. To inhibit brain ACE captopril (D-3-mercaptopropanoyl-L-proline) was given orally (p.o., 50 mg/kg) or intracerebroventricularly (i.c.v., 5 micrograms/rat). 3. Captopril given p.o. but not i.c.v. significantly enhanced stereotypy, overall number of conditioned avoidance responses, and decreased blood pressure. 4. No statistically significant influence of captopril given by either route on the number of crossings, rearings and bar approaches in the open field, performance of passive avoidance and number of correct choices as well as the speed of running for food in the T-maze was observed. 5. In conclusion, a small decrease of the activity of nigrostriatal dopaminergic system caused by the decrease of AII and/or increase of bradykinin, substance P, enkephalins and neurotensin in brain resulting from ACE inhibition is postulated.

摘要

研究了脑内血管紧张素转换酶（ACE，EC 3.4.15.1）抑制对大鼠精神运动、探索、刻板和认知行为的影响。为抑制脑内ACE，口服（p.o.，50 mg/kg）或脑室内注射（i.c.v.，5微克/大鼠）卡托普利（D-3-巯基丙酰-L-脯氨酸）。3. 口服而非脑室内注射卡托普利显著增强了刻板行为、条件性回避反应的总数，并降低了血压。4. 未观察到两种给药途径的卡托普利对旷场试验中的穿越次数、直立次数和触棒次数、被动回避行为表现、正确选择次数以及T迷宫中奔向食物的速度有统计学显著影响。5. 总之，推测ACE抑制导致脑内AII减少和/或缓激肽、P物质、脑啡肽和神经降压素增加，从而引起黑质纹状体多巴胺能系统活性轻微降低。