Research Unit for Experimental Neonatal Respiratory Physiology, Cruces University Hospital, Bizkaia, Spain.
Pediatr Res. 2012 Oct;72(4):393-9. doi: 10.1038/pr.2012.90. Epub 2012 Jul 13.
Aerosolized perfluorocarbon (PFC) has been proposed as an alternative method of PFC administration; however, the efficacy of aerosolized PFC in a preterm animal model has not yet been demonstrated.
Twelve preterm lambs were randomized to two groups: a perfluorodecalin (PFD) aerosol group (n = 6) receiving 10 ml/kg/h of PFD delivered by an intratracheal inhalation catheter followed by 4 h of mechanical ventilation (MV) or the control group, in which animals (n = 6) were managed for 6 h with MV. Gas exchange, pulmonary mechanics, cardiovascular parameters, and cerebral blood flow (CBF) were measured.
Both groups developed hypoxia, hypercarbia, and acidosis at baseline. Aerosolized PFD improved oxygenation (P < 0.0001) and pulmonary mechanics (P < 0.0001) and changed carbon dioxide values to normal physiological levels, unlike the treatment given to the controls (P < 0.0003). The time course of mean arterial blood pressure and CBF were significantly affected by PFD aerosolization, especially during the first hour of life. CBF gradually decreased during the first hour in the PFD aerosol group and remained stable until the end of the follow-up, whereas CBF remained higher in the control group (P < 0.0028).
Aerosolized PFD improves pulmonary function in preterm lambs and should be further investigated as an alternative mode of PFC administration.
已提出将气溶胶化全氟碳化合物（PFC）作为 PFC 给药的替代方法；然而，在早产动物模型中，气溶胶化 PFC 的疗效尚未得到证实。
将 12 只早产羔羊随机分为两组：全氟癸烷（PFD）气雾剂组（n = 6），通过气管内吸入导管给予 10 ml/kg/h 的 PFD，随后进行 4 h 的机械通气（MV）或对照组，其中 6 只动物（n = 6）在 MV 下接受 6 h 的治疗。测量气体交换、肺力学、心血管参数和脑血流（CBF）。
两组在基线时均出现缺氧、高碳酸血症和酸中毒。与对照组相比，PFD 气雾剂改善了氧合（P < 0.0001）和肺力学（P < 0.0001），并将二氧化碳值改变为正常生理水平（P < 0.0003）。平均动脉血压和 CBF 的时间进程受到 PFD 气溶胶化的显著影响，尤其是在生命的第一个小时内。在 PFD 气雾剂组中，CBF 在第一个小时逐渐下降，直到随访结束时保持稳定，而在对照组中 CBF 保持较高水平（P < 0.0028）。
PFD 气雾剂改善了早产羔羊的肺功能，应进一步作为 PFC 给药的替代方式进行研究。
