Research Unit for Experimental Neonatal Respiratory Physiology, Cruces University Hospital, Barakaldo, Bizkaia, Spain.
PLoS One. 2013;8(2):e56127. doi: 10.1371/journal.pone.0056127. Epub 2013 Feb 13.
Surfactant (SF) and partial liquid ventilation (PLV) improve gas exchange and lung mechanics in neonatal RDS. However, variations in the effects of SF and PLV with degree of lung immaturity have not been thoroughly explored.
Experimental Neonatal Respiratory Physiology Research Unit, Cruces University Hospital.
Prospective, randomized study using sealed envelopes.
36 preterm lambs were exposed (at 125 or 133-days of gestational age) by laparotomy and intubated. Catheters were placed in the jugular vein and carotid artery.
All the lambs were assigned to one of three subgroups given: 20 mL/Kg perfluorocarbon and managed with partial liquid ventilation (PLV), surfactant (Curosurf®, 200 mg/kg) or (3) no pulmonary treatment (Controls) for 3 h.
Cardiovascular parameters, blood gases and pulmonary mechanics were measured. In 125-day gestation lambs, SF treatment partially improved gas exchange and lung mechanics, while PLV produced significant rapid improvements in these parameters. In 133-day lambs, treatments with SF or PLV achieved similarly good responses. Neither surfactant nor PLV significantly affected the cardiovascular parameters.
SF therapy response was more effective in the older gestational age group whereas the effectiveness of PLV therapy was not gestational age dependent.
表面活性剂（SF）和部分液体通气（PLV）可改善新生儿呼吸窘迫综合征（RDS）的气体交换和肺力学。然而，SF 和 PLV 的效果随肺成熟度的变化尚未得到充分探索。
十字大学医院实验新生儿呼吸生理学研究单位。
使用密封信封的前瞻性随机研究。
36 只早产羔羊通过剖腹术和插管暴露（在 125 或 133 天的胎龄）。将导管放置在颈静脉和颈动脉中。
所有羔羊均分为三组之一，每组接受：20 mL/Kg 全氟碳和部分液体通气（PLV）管理，表面活性剂（Curosurf®，200 mg/kg）或（3）无肺部治疗（对照组）3 小时。
测量心血管参数、血气和肺力学。在 125 天胎龄的羔羊中，SF 治疗部分改善了气体交换和肺力学，而 PLV 则显著迅速改善了这些参数。在 133 天的羔羊中，SF 或 PLV 的治疗产生了类似的良好反应。表面活性剂和 PLV 均未显著影响心血管参数。
SF 治疗的反应在较年长的胎龄组中更有效，而 PLV 治疗的效果不受胎龄的影响。
