Tsuji Atsushi B, Kato Koichi, Sugyo Aya, Okada Maki, Sudo Hitomi, Yoshida Chisato, Wakizaka Hidekatsu, Zhang Ming-Rong, Saga Tsuneo
Diagnostic Imaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
Nucl Med Commun. 2012 Oct;33(10):1058-64. doi: 10.1097/MNM.0b013e328356efb0.
2-Deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) accumulates in tumors and also during active inflammation, including therapy-related inflammation. Additional PET tracers that are less avid to inflammation could be useful in differentiating cancer from inflammation and could complement the limitation of [18F]FDG-PET. 2-Amino-[3-11C]isobutyric acid ([3-11C]AIB) is a potential PET tracer for this purpose. We compared [3-11C]AIB and [18F]FDG uptakes in tumors and acute inflammation in a mouse model.
Acute inflammatory lesions were induced in the hind legs of tumor-bearing mice by intramuscular injection of turpentine, and we conducted biodistribution and dynamic PET studies on [3-11C]AIB and [18F]FDG.
[3-11C]AIB tumor uptake increased with time and was statistically significantly higher than [18F]FDG uptake. In inflamed muscles, [3-11C]AIB uptake was statistically significantly lower than [18F]FDG uptake, and the tumor-to-inflammation ratio for [3-11C]AIB was statistically significantly higher than that for [18F]FDG.
[3-11C]AIB accumulates more selectively in tumor tissue than does [18F]FDG and thus has the potential of discriminating between tumors and inflammatory lesions better and of complementing the limitation of [18F]FDG.
2-脱氧-2-[18F]氟-D-葡萄糖（[18F]FDG）在肿瘤以及包括治疗相关炎症在内的活动性炎症过程中都会蓄积。对炎症摄取较低的其他正电子发射断层显像（PET）示踪剂可能有助于鉴别癌症与炎症，并可弥补[18F]FDG-PET的局限性。2-氨基-[3-11C]异丁酸（[3-11C]AIB）是用于此目的的一种潜在PET示踪剂。我们在小鼠模型中比较了[3-11C]AIB和[18F]FDG在肿瘤和急性炎症中的摄取情况。
通过肌肉注射松节油在荷瘤小鼠的后腿诱导急性炎症病变，然后我们对[3-11C]AIB和[18F]FDG进行了生物分布和动态PET研究。
[3-11C]AIB的肿瘤摄取随时间增加，且在统计学上显著高于[18F]FDG摄取。在发炎的肌肉中，[3-11C]AIB的摄取在统计学上显著低于[18F]FDG摄取，并且[3-11C]AIB的肿瘤与炎症比值在统计学上显著高于[18F]FDG。
与[18F]FDG相比，[3-11C]AIB在肿瘤组织中的蓄积更具选择性，因此有潜力更好地区分肿瘤和炎性病变，并弥补[18F]FDG的局限性。
