Department of Nuclear Medicine, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College (CAMS & PUMC), Beijing, China.
Theranostics. 2013 Jun 24;3(7):448-66. doi: 10.7150/thno.6592. Print 2013.
Inflammation plays a significant role in many disease processes. Development in molecular imaging in recent years provides new insight into the diagnosis and treatment evaluation of various inflammatory diseases and diseases involving inflammatory process. Positron emission tomography using (18)F-FDG has been successfully applied in clinical oncology and neurology and in the inflammation realm. In addition to glucose metabolism, a variety of targets for inflammation imaging are being discovered and utilized, some of which are considered superior to FDG for imaging inflammation. This review summarizes the potential inflammation imaging targets and corresponding PET tracers, and the applications of PET in major inflammatory diseases and tumor associated inflammation. Also, the current attempt in differentiating inflammation from tumor using PET is also discussed.
炎症在许多疾病过程中起着重要作用。近年来分子影像学的发展为各种炎症性疾病和涉及炎症过程的疾病的诊断和治疗评估提供了新的见解。正电子发射断层扫描（PET）使用（18）F-FDG 已成功应用于临床肿瘤学和神经病学以及炎症领域。除葡萄糖代谢外，正在发现和利用各种炎症成像的靶标，其中一些靶标被认为比 FDG 更适合炎症成像。本文综述了潜在的炎症成像靶标及其相应的 PET 示踪剂，以及 PET 在主要炎症性疾病和肿瘤相关炎症中的应用。此外，还讨论了目前使用 PET 区分炎症和肿瘤的尝试。
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