Günter C I, Machens H-G
Clinic for Plastic and Hand Surgery, University Hospital rechts der Isar, Technische Universität München, Munich, Germany.
Eur Surg Res. 2012;49(1):16-23. doi: 10.1159/000339860. Epub 2012 Jul 11.
The prevalence of chronic wounds is closely correlated to the aging population and so-called civilizational diseases. Therefore, they are causing morbidity and mortality of millions of patients worldwide, with an unbroken upward trend. As a consequence, chronic wounds induce enormous and rapidly growing costs for our health care systems and society in general. Thus, medically effective and cost-efficient treatment methods are urgently needed. Methods of 'regenerative medicine' might offer innovative scientific solutions, including the use of stem cells, growth factors and new bioactive materials. These tools are experimentally well described but clinically poorly performed. The main reasons for this are both legislative and economic. This review describes state-of-the-art techniques, up-to-date research projects, innovative preclinical and clinical approaches in wound care, and activities to translate these innovative techniques into clinical routine.
慢性伤口的患病率与人口老龄化和所谓的文明病密切相关。因此，它们正在导致全球数百万患者发病和死亡，且呈持续上升趋势。结果，慢性伤口给我们的医疗保健系统和整个社会带来了巨大且迅速增长的成本。因此，迫切需要医学上有效且具有成本效益的治疗方法。“再生医学”方法可能提供创新的科学解决方案，包括使用干细胞、生长因子和新型生物活性材料。这些工具在实验上已有充分描述，但在临床上的应用却不尽人意。主要原因包括立法和经济方面。本综述描述了伤口护理领域的最新技术、最新研究项目、创新的临床前和临床方法，以及将这些创新技术转化为临床常规操作的活动。
