Neurol Sci. 2013 Jun;34(6):1003-4. doi: 10.1007/s10072-012-1153-3. Epub 2012 Jul 14.
Valproate is one of the most used anti-epileptic drugs. Its common side effects are nausea, vomiting, weight gain, hair loss, tremor, changes in behavior, slowed thinking and impaired liver function. Blood dyscrasias are also relatively frequent and a few studies reported changes in serum immunoglobulin concentrations with valproate treatment. We describe a case of panhypogammaglobulinemia with transient pancytopenia due to valproate. Pancytopenia was recovered after discontinuation of valproate but panhypogammaglobulinemia has been persisting. Intravenous immunoglobulin is being administrated monthly. Previous reports describe that other sodium channel blockers, such as phenytoin and carbamazepine, have been associated with hypogammaglobulinemia. This report also suggests that immunodeficiencies can be caused by valproate.
丙戊酸钠是最常用的抗癫痫药物之一。其常见的副作用有恶心、呕吐、体重增加、脱发、震颤、行为改变、思维迟钝和肝功能损害。血液疾病也相对频繁，一些研究报告了丙戊酸钠治疗后血清免疫球蛋白浓度的变化。我们描述了一例丙戊酸钠引起的全低丙种球蛋白血症伴短暂性全血细胞减少症。丙戊酸钠停药后全血细胞减少症得到恢复，但全低丙种球蛋白血症仍持续存在。每月给予静脉注射免疫球蛋白。以前的报告描述了其他钠通道阻滞剂，如苯妥英钠和卡马西平，与低丙种球蛋白血症有关。本报告还表明，丙戊酸钠也可引起免疫缺陷。
