癫痫与IgA缺乏——丙戊酸钠的影响
Epilepsy and IgA deficiency--the effect of sodium valproate.
作者信息
Joubert P H, Aucamp A K, Potgieter G M, Verster F
出版信息
S Afr Med J. 1977 Oct 8;52(16):642-4.
PMID:337537
Abstract
IgA deficiency (less than 80 IU/ml serum) occurred in 29% of 41 epileptic patients on anticonvulsant therapy. Sodium valproate users had significantly lower mean IgA levels (102 IU/ml) than non-users (151 IU/ml) and had a significantly higher incidence of IgA deficiency (50%) than non-users (16%). The occurrence of IgA deficiency did not appear to be related to age, sex, number of drugs used or to serum anticonvulsant levels.
摘要
41例接受抗惊厥治疗的癫痫患者中，29%出现IgA缺乏（血清IgA低于80 IU/ml）。服用丙戊酸钠的患者平均IgA水平（102 IU/ml）显著低于未服用者（151 IU/ml），且IgA缺乏的发生率（50%）显著高于未服用者（16%）。IgA缺乏的发生似乎与年龄、性别、用药数量或血清抗惊厥药物水平无关。
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