Poduval T B, Seshadri M, Thakur V S, Chauhan P S
Biomedical Group, Bhabha Atomic Research Centre, Bombay, India.
Indian J Exp Biol. 1990 Sep;28(9):821-4.
Mice belonging to F8, F12, F14 and F20 generation of a multigeneration study reared on 20% (v/v) ethanol in water as the sole drinking source were investigated for their immune competence using various parameters. The results indicated lack of any significant effect on delayed type hypersensitivity to dinitro fluorobenzene (DNFB) or sheep red blood cells (SRBC) in mice consuming ethanol. Further, alloskin graft and tumor graft response was similar in both ethanol and water fed mice. Humoral response to SRBC was also intact. However, NK cell activity was reduced significantly in ethanol fed mice. Phagocytic index as assessed by the carbon clearance test was also reduced considerably in mice consuming ethanol. The results clearly indicate that ethanol per se has a significant effect on the nonspecific limb of the immune system, in chronically fed mice.
在一项多代研究中，将F8、F12、F14和F20代小鼠以20%（v/v）乙醇水溶液作为唯一饮用水源进行饲养，然后使用各种参数对其免疫能力进行研究。结果表明，饮用乙醇的小鼠对二硝基氟苯（DNFB）或绵羊红细胞（SRBC）的迟发型超敏反应没有受到任何显著影响。此外，在喂食乙醇和水的小鼠中，同种皮肤移植和肿瘤移植反应相似。对SRBC的体液反应也未受影响。然而，喂食乙醇的小鼠的NK细胞活性显著降低。通过碳清除试验评估的吞噬指数在饮用乙醇的小鼠中也大幅降低。结果清楚地表明，在长期喂食的小鼠中，乙醇本身对免疫系统的非特异性分支有显著影响。
