Metabolic Health, Rowett Institute of Nutrition and Health, University of Aberdeen, Aberdeen, Scotland, UK.
Adv Nutr. 2012 Jul 1;3(4):499-505. doi: 10.3945/an.112.002121.
Diet is a critical factor in the maintenance of human cellular defense systems, immunity, inflammation, redox regulation, metabolism, and DNA repair that ensure optimal health and reduce disease risk. Assessment of dietary modulation of cellular defense systems in humans has been limited due to difficulties in accessing target tissues. Notably, peripheral blood gene expression profiles associated with nonhematologic disease are detectable. Coupled with recent innovations in gene expression technologies, gene expression profiling of human blood to determine predictive markers associated with health status and dietary modulation is now a feasible prospect for nutrition scientists. This review focuses on cellular defense system gene expression profiling of human whole blood and the opportunities this presents, using recent technological advances, to predict health status and benefits conferred by diet.
饮食是维持人体细胞防御系统、免疫力、炎症、氧化还原调节、代谢和 DNA 修复的关键因素，这些因素可确保人体处于最佳健康状态，降低疾病风险。由于难以接触到目标组织，因此对饮食调节人体细胞防御系统的评估受到限制。值得注意的是，与非血液疾病相关的外周血基因表达谱是可检测到的。最近基因表达技术的创新，使利用人类血液的基因表达谱来确定与健康状况和饮食调节相关的预测标志物成为营养科学家的可行前景。本综述重点介绍了人类全血的细胞防御系统基因表达谱，并利用最近的技术进步展示了这一方法在预测健康状况和饮食益处方面的潜力。
