维生素 D 与流感。
Vitamin D and influenza.
机构信息
Marshfield Clinic Research Foundation, Marshfield, WI, USA.
出版信息
Adv Nutr. 2012 Jul 1;3(4):517-25. doi: 10.3945/an.112.002162.
Abstract
Vitamin D has become increasingly recognized in the literature for its extra-skeletal roles, including an effect on inflammation and the immune response to infection. Our goal was to describe the role of vitamin D in the immune response and implications for the risk of influenza infection in humans. In this review, we first consider literature that provides molecular and genetic support to the idea that vitamin D is related to the adaptive and innate immune responses to influenza infection in vitro and in animal models. We then discuss observational studies and randomized controlled trials of vitamin D supplementation in humans. Finally, we consider some of the knowledge gaps surrounding vitamin D and immune response that must be filled.
摘要
维生素 D 在文献中因其骨骼外作用而越来越受到关注，包括对炎症和感染的免疫反应的影响。我们的目标是描述维生素 D 在免疫反应中的作用及其对人类流感感染风险的影响。在这篇综述中，我们首先考虑了提供分子和遗传支持的文献，这些文献表明维生素 D 与体外和动物模型中流感感染的适应性和固有免疫反应有关。然后，我们讨论了维生素 D 补充在人类中的观察性研究和随机对照试验。最后，我们考虑了一些围绕维生素 D 和免疫反应的知识空白，这些空白必须填补。
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Vitamin D supplementation does not increase immunogenicity of seasonal influenza vaccine in HIV-infected adults.补充维生素D不会增加HIV感染成人中季节性流感疫苗的免疫原性。
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Intensive cytokine induction in pandemic H1N1 influenza virus infection accompanied by robust production of IL-10 and IL-6.大流行性 H1N1 流感病毒感染时细胞因子的强烈诱导，伴有 IL-10 和 IL-6 的大量产生。
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Seasonal H1N1 influenza virus infection induces cross-protective pandemic H1N1 virus immunity through a CD8-independent, B cell-dependent mechanism.季节性 H1N1 流感病毒感染通过非 CD8 依赖、B 细胞依赖的机制诱导交叉保护性大流行 H1N1 病毒免疫。
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