Department of Respiratory Diseases, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan Province 572013, China.
Inflammation. 2012 Dec;35(6):1833-43. doi: 10.1007/s10753-012-9504-z.
This study explored the association of sepsis prognosis with dynamic changes in serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and its polymorphisms. We enrolled 80 subjects with sepsis and 80 controls. Serum sTREM-1 was tested on days 1, 3, 5, 7, 10, and 14. PCR sequencing was performed to detect TREM-1 genetic variation on its four exons. sTREM-1 levels were significantly higher in the nonsurvivor than in the survivor group (p < 0.001), and those at each time point were the same (p ≤ 0.001). Of the three tested TREM-1 SNPs (rs144672509, rs2234237, and rs2234246), only rs2234237 (Ser25Thr) was significantly associated with sepsis prognosis in three inheritance models (p < 0.05). However, there was no relationship between TREM-1 polymorphism and dynamic concentration of sTREM-1. Logistic regression showed that sTREM-1, APACHE II, and rs2234237 polymorphism are risk factors for prognosis. Dynamic changes in serum sTREM-1 and rs2234237 polymorphism could be used in sepsis prognosis assessment.
本研究探讨了血清可溶性髓系细胞触发受体-1（sTREM-1）及其多态性的动态变化与脓毒症预后的关系。我们纳入了 80 例脓毒症患者和 80 例对照。在第 1、3、5、7、10 和 14 天检测血清 sTREM-1。通过 PCR 测序检测 TREM-1 四个外显子的遗传变异。非幸存者的血清 sTREM-1 水平明显高于幸存者（p<0.001），并且各时间点的水平相同（p≤0.001）。在三种检测到的 TREM-1 SNP（rs144672509、rs2234237 和 rs2234246）中，只有 rs2234237（Ser25Thr）在三种遗传模型中与脓毒症预后显著相关（p<0.05）。然而，TREM-1 多态性与 sTREM-1 的动态浓度之间没有关系。逻辑回归显示，sTREM-1、APACHE II 和 rs2234237 多态性是预后的危险因素。血清 sTREM-1 和 rs2234237 多态性的动态变化可用于脓毒症预后评估。
