De Gaetano F, Ambrosio L, Raucci M G, Marotta A, Catauro M
Department of Materials and Productions Engineering, University of Naples, Federico II Piazzale Tecchio, 80125 Naples, Italy.
J Mater Sci Mater Med. 2005 Mar;16(3):261-5. doi: 10.1007/s10856-005-6688-x.
Silica, calcium (5 mol%) silicate and silica/polycaprolactone hybrid inorganic/organic amorphous materials, all mixed with sodium ampicillin, a broad-spectrum antibiotic, have been synthesized by sol-gel method. The amorphous nature of the gels was ascertained by X-ray diffraction analysis. Release kinetics in a simulate body fluid (SBF) have been subsequently investigated. The amount of sodium ampicillin released has been detected by UV-Vis spectroscopy and SEM. The release kinetics seems to occur in more than one stage. Finally FTIR measurements and SEM micrograph showed the formation of a hydroxyapatite layer on the surface of the samples soaked in SBF. All data showed that these materials could be used as drug delivery bioactive systems.
二氧化硅、钙（5摩尔%）硅酸盐以及二氧化硅/聚己内酯混合无机/有机无定形材料，均与广谱抗生素氨苄西林钠混合，已通过溶胶-凝胶法合成。通过X射线衍射分析确定了凝胶的无定形性质。随后研究了在模拟体液（SBF）中的释放动力学。通过紫外-可见光谱和扫描电子显微镜检测了氨苄西林钠的释放量。释放动力学似乎分多个阶段发生。最后，傅里叶变换红外光谱测量和扫描电子显微镜显微照片显示，浸泡在SBF中的样品表面形成了羟基磷灰石层。所有数据表明，这些材料可作为药物递送生物活性系统。
