Division of Pulmonary and Critical Care Medicine, Department of Medicine, Eastern Virginia Medical School, Norfolk, VA, USA.
Front Endocrinol (Lausanne). 2012 Jul 11;3:87. doi: 10.3389/fendo.2012.00087. eCollection 2012.
Obesity results from alterations in the body's regulation of energy intake, expenditure, and storage. Animal and human data demonstrate that phylogenic changes occur in the microbiota composition in obese individuals. Furthermore, evidence from animal models suggest that the alterations of the gut microbiota with obesity results in increased energy extraction and lipid deposition, altered release of entero-hormones, increased intestinal permeability and metabolic endotoxemia. Treatment with pre- and probiotics may reverse many of metabolic effects linked with the altered microbiota in obese patients. The gut microbiota is, therefore, a potential nutritional and pharmacological target for the management of obesity and obesity-related disorders.
肥胖是由于机体能量摄入、消耗和储存的调节发生改变所致。动物和人类研究资料均表明，肥胖个体的微生物组成发生了种系发生变化。此外，动物模型研究证据提示，肥胖导致肠道微生物群改变，从而增加能量提取和脂质沉积，改变肠促激素释放，增加肠道通透性和代谢性内毒素血症。应用益生菌和益生元治疗可能逆转与肥胖患者微生物群改变相关的许多代谢效应。因此，肠道微生物群是肥胖及其相关疾病管理的一个有潜力的营养和药理学治疗靶点。
