Louvain Drug Research Institute, Metabolism and Nutrition Research Group, Université Catholique de Louvain, Brussels, Belgium.
Curr Diab Rep. 2011 Jun;11(3):154-9. doi: 10.1007/s11892-011-0191-1.
Several reviews recently explored how the gut microbiota was able to control host energy metabolism, and thereby the development of adiposity. In this review, we focused on the state of the art that supports a link between the gut microbiota composition and activity, and the management of glycemia associated with overweight and diabetes. Several microbial-derived compounds are related to disturbances of glucose homeostasis including the gram-negative-derived lipopolysaccharides. Some nutrients with prebiotic properties, which escape the digestion in the upper part of the gut, modify the composition of the gut microbiota in favor of bacteria that could play a beneficial role on glucose homeostasis, namely by modulating the endocrine function of the gut, and by reinforcing the gut barrier. Adequate intervention studies in diabetic patients are required to assess the relevance of those experimental data for human health.
最近有几项综述探讨了肠道微生物群如何控制宿主的能量代谢，从而影响肥胖的发展。在这篇综述中，我们重点介绍了支持肠道微生物群组成和活性与超重和糖尿病相关血糖管理之间联系的最新研究进展。几种微生物衍生的化合物与葡萄糖稳态紊乱有关，包括革兰氏阴性菌衍生的脂多糖。一些具有益生元特性的营养素可以逃脱上消化道的消化，从而改变肠道微生物群的组成，有利于可能对葡萄糖稳态发挥有益作用的细菌，即通过调节肠道的内分泌功能，以及加强肠道屏障。需要在糖尿病患者中进行充分的干预研究，以评估这些实验数据与人类健康的相关性。
