Alanís-Garza Blanca, Salazar-Aranda Ricardo, Ramírez-Durón Rosalba, Garza-González Elvira, Waksman de Torres Noemí
Department of Analytical Chemistry, Faculty of Medicine, Universidad Autónoma de Nuevo León, P.O. Box 2316, Sucursal Tecnológico, Monterrey, N.L., 64841 México.
Nat Prod Commun. 2012 May;7(5):597-8.
Bioassay-guided fractionation of the minor active fractions obtained from the root bark of Leucophyllumfrutescens (Berl.) I. M. Johnst. led to isolation from the n-hexane extract of a new compound with moderate activity against the H37Rv Mycobacterium tuberculosis strain (MIC 63 microg/mL), and low cytotoxicity, as shown by the IC5o against Vero cells. The compound was identified by 1D/2D NMR spectroscopy a s2',5"-dimethoxysesamin.
对从紫叶矮樱（Leucophyllum frutescens (Berl.) I. M. Johnst.）根皮中获得的次要活性馏分进行生物测定指导的分级分离，从正己烷提取物中分离出一种新化合物，该化合物对结核分枝杆菌H37Rv菌株具有中等活性（MIC为63μg/mL），且细胞毒性较低，如对Vero细胞的IC50所示。通过一维/二维核磁共振光谱法将该化合物鉴定为2',5"-二甲氧基芝麻素。
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