OUYANG Tianbin, TANG Shi-xiong, ZHANG Li-tao, YAO Shou-guo, ZHANG Xu-qun, LU Xu, CHEN Xing
Department of Otorhinolaryngology Head and Neck Surgery, Ningbo no.1 Hospital, Ningbo 315010, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 Apr;47(4):320-3.
To determine the clinical value of 24 h double-probe pH-metry for the diagnosis and treatment of laryngopharyngeal reflux (LPR).
According to the pH-metry results (whether the reflux events record in the upper esophagus is more than 6.9), patients of refractory pharyngolaryngitis were divided into LPR and control groups (each of 17 cases). All patients treated with anti-acid therapy and conventional pharyngo-laryngitis therapy. Correlation between pH-metry and the reflux symptom index (RSI), the reflux symptom index (RFI) were analyzed. Changes of the RSI and RFI in different group were calculated in post-treatment.
In the LPR group, the median reflux events of the upright time were higher than the supine time (Z = -3.62, P < 0.01), but the difference was not discovered in the control group (Z = -0.60, P > 0.05). There was no statistical difference between RSI, RSI and RFS with pH-metry, and with moderate concordance (k were 0.47, 0.53, P < 0.01, respectively). Compared to pre-treatment, the RSI and RFI were decreased both in LPR group and control group, Amplitude decreased in LPR group significantly higher than the control groups, with statistical difference (t were 3.74, 3.01, P < 0.01, respectively).
The 24 h double-probe pH-metry is significant for the anti-acid therapy of LPR.
探讨24小时双探头pH监测在喉咽反流（LPR）诊断及治疗中的临床价值。
依据pH监测结果（食管上段反流事件记录pH值是否大于6.9），将难治性咽炎患者分为LPR组和对照组（每组各17例）。所有患者均接受抗酸治疗及常规咽炎治疗。分析pH监测与反流症状指数（RSI）、反流因子指数（RFI）之间的相关性。计算治疗后不同组RSI和RFI的变化。
LPR组直立位反流事件中位数高于仰卧位（Z = -3.62，P < 0.01），而对照组未发现差异（Z = -0.60，P > 0.05）。pH监测与RSI、RFI之间无统计学差异，且具有中度一致性（k分别为0.47、0.53，P < 0.01）。与治疗前相比，LPR组和对照组的RSI和RFI均降低，LPR组下降幅度显著高于对照组，差异有统计学意义（t分别为3.74、3.01，P < 0.01）。
24小时双探头pH监测对LPR的抗酸治疗具有重要意义。
