Departments of Gastroenterology, Peking University People's Hospital, Beijing, China.
Departments of Otorhinolaryngology , Peking University People's Hospital, Beijing, China.
J Neurogastroenterol Motil. 2014 Jul 31;20(3):347-51. doi: 10.5056/jnm13138.
BACKGROUND/AIMS: To draw a normative database of laryngopharynx pH profile in Chinese subjects.
Normal volunteers were recruited from "www.Ganji.com" and People's hospital between May 2008 and December 2009. The Restech pH Probes were calibrated in pH 7 and pH 4 buffer solutions according to the manufacturer's instructions. Each volunteer was asked to wear the device for a 24-hour period and was encouraged to participate in normal daily activities.
The healthy volunteers consisted of 20 males and 9 females with a median age of 23 years (interquartile range, 21 to 32 years). The 95th percentiles for % total times at pH < 4, pH < 4.5, pH < 5.0 and pH < 5.5 for the oropharynx pH catheter were 0.06%, 1.01%, 7.23% and 27.34%, respectively. The 95th percentile for number of reflux events within the 24-hour period at pH < 4, pH < 4.5, pH < 5.0 and pH < 5.5 were 2.0, 18.0, 107.5 and 284.5, respectively.
This is the first study to systematically assess the degree of reflux detected by the new pH probe in healthy asymptomatic Chinese volunteers and to report normative values in Chinese people. Using an oropharyngeal pH catheter to monitor laryngopharyngeal reflux indicated that in healthy Chinese, reflux should be considered normal if the percent time at pH less than 4.5 is no more than 1%.
背景/目的：绘制中国人喉咽部 pH 曲线的正常参考值数据库。
正常志愿者从“www.Ganji.com”和人民医院招募，时间为 2008 年 5 月至 2009 年 12 月。根据制造商的说明，用 Restech pH 探头在 pH 7 和 pH 4 缓冲液中校准。要求每位志愿者佩戴设备 24 小时，并鼓励其参与正常的日常活动。
健康志愿者包括 20 名男性和 9 名女性，中位数年龄为 23 岁（四分位间距，21 至 32 岁）。口咽 pH 导管的 pH < 4、pH < 4.5、pH < 5.0 和 pH < 5.5 的总时间 95%百分位值分别为 0.06%、1.01%、7.23%和 27.34%。24 小时内 pH < 4、pH < 4.5、pH < 5.0 和 pH < 5.5 的反流事件数 95%百分位值分别为 2.0、18.0、107.5 和 284.5。
这是第一项系统评估新 pH 探头在无症状健康中国志愿者中检测到的反流程度并报告中国人正常值的研究。使用咽 pH 导管监测喉咽反流，如果 pH < 4.5 的时间百分比不超过 1%，则可认为反流是正常的。
