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碘摄入增加实验性自身免疫性甲状腺炎大鼠血清和甲状腺中 IP-10 的表达。

Iodine Intake Increases IP-10 Expression in the Serum and Thyroids of Rats with Experimental Autoimmune Thyroiditis.

机构信息

Institute for Iodine Deficiency Disorders Control, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health, Harbin 150081, China.

Institute for Kashin-Beck Disease Control, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, 157 Bao Jian Road, Harbin 150081, China.

出版信息

Int J Endocrinol. 2014;2014:581069. doi: 10.1155/2014/581069. Epub 2014 Feb 25.

DOI:10.1155/2014/581069
PMID:24707288
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3953660/
Abstract

Here, we sought to establish an experimental autoimmune thyroiditis rat model induced by bovine thyroglobulin (bTg) injection and to investigate pathological changes and variations in serum interferon- γ -inducible protein of 10 kDa (IP-10) in thyroid tissue following iodine treatment. Four-week-old female Lewis rats (n = 135) were randomly divided into normal (NC), thyroglobulin (TG), HI, HI+TG, HII, and HII+TG groups; rats in the NC and TG groups drank only distilled water (iodine concentration: 10  μ g/L), rats in the HI and HI+TG groups were given water containing 25.7 mg/L iodine, and rats in the HII and HII+TG groups were given water containing 423.3 mg/L iodine. Rats in the TG, HI+TG, and HII+TG groups were immunized with 0.1 mL bTg (8 mg/mL) in incomplete Freund's adjuvant once every 2 weeks for 6 weeks. Compared with the NC group, the TG, HI+TG, and HII+TG groups exhibited higher iodine intake and increased thyroid weights with increasing iodine doses (P < 0.05). The high iodine intake in the TG group was associated with increased CD4(+) T cells and serum IP-10. Thus, high iodine consumption aggravated the inflammatory reaction in the thyroid and mild high iodine consumption increased serum IP-10 levels after induction with bTg.

摘要

在这里，我们试图建立一种由牛甲状腺球蛋白（bTg）注射诱导的实验性自身免疫性甲状腺炎大鼠模型，并研究碘处理后甲状腺组织中干扰素-γ诱导蛋白 10kDa（IP-10）的病理变化和变化。将 4 周龄雌性 Lewis 大鼠（n = 135）随机分为正常（NC）、甲状腺球蛋白（TG）、高碘（HI）、高碘+甲状腺球蛋白（HI+TG）、超高碘（HII）和超高碘+甲状腺球蛋白（HII+TG）组；NC 和 TG 组仅饮用蒸馏水（碘浓度：10μg/L），HI 和 HI+TG 组给予含 25.7μg/L 碘的水，HII 和 HII+TG 组给予含 423.3μg/L 碘的水。TG、HI+TG 和 HII+TG 组大鼠每 2 周用 0.1mL 牛甲状腺球蛋白（8mg/mL）在不完全弗氏佐剂中免疫一次，共 6 周。与 NC 组相比，TG、HI+TG 和 HII+TG 组碘摄入量增加，甲状腺重量随碘剂量增加而增加（P < 0.05）。TG 组高碘摄入与 CD4（+）T 细胞增多和血清 IP-10 增加有关。因此，高碘摄入加重了甲状腺的炎症反应，轻度高碘摄入在 bTg 诱导后增加了血清 IP-10 水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e864/3953660/aae68ace0d80/IJE2014-581069.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e864/3953660/c7ee1cb865ab/IJE2014-581069.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e864/3953660/d6cd1f380971/IJE2014-581069.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e864/3953660/3f3c738c5e44/IJE2014-581069.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e864/3953660/58ce913cca3b/IJE2014-581069.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e864/3953660/aae68ace0d80/IJE2014-581069.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e864/3953660/c7ee1cb865ab/IJE2014-581069.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e864/3953660/d6cd1f380971/IJE2014-581069.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e864/3953660/3f3c738c5e44/IJE2014-581069.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e864/3953660/58ce913cca3b/IJE2014-581069.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e864/3953660/aae68ace0d80/IJE2014-581069.005.jpg

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