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小儿青光眼小梁切除术与小梁切开-小梁切除术联合治疗的对比

Trabeculectomy versus combined trabeculotomy-trabeculectomy in pediatric glaucoma.

作者信息

Lawrence Scott D, Netland Peter A

出版信息

J Pediatr Ophthalmol Strabismus. 2012 Nov-Dec;49(6):359-65. doi: 10.3928/01913913-20120710-06. Epub 2012 Jul 17.

Abstract

PURPOSE

To compare outcomes between trabeculectomy and combined trabeculotomy-trabeculectomy in children with glaucoma.

METHODS

This was a retrospective, comparative study of 40 eyes in 33 patients with pediatric glaucoma: 17 eyes treated with trabeculectomy and 23 eyes treated with combined trabeculotomy-trabeculectomy. Both groups were treated with intraoperative mitomycin C. Success was defined as intraocular pressure (IOP) of 21 mm Hg or less and greater than 5 mm Hg with no additional glaucoma surgery.

RESULTS

Mean follow-up was 38.3 months. There was no significant difference in mean IOP lowering between groups during the follow-up period. Log-rank survival analysis showed a significantly higher success rate after combined surgery compared with trabeculectomy (P = .027). Treatment failures occurred in 5 patients with trabeculectomy and in 2 patients undergoing combined trabeculotomy-trabeculectomy. Failures resulted from increased IOP (n = 3) or hypotony (n = 4). There were no significant differences in complications observed after surgery in both groups.

CONCLUSION

Trabeculectomy and combined trabeculotomy-trabeculectomy with mitomycin C were equally effective at lowering average IOP in children. Combined trabeculotomy-trabeculectomy was associated with greater long-term success.

摘要

目的

比较小梁切除术与小梁切开联合小梁切除术治疗儿童青光眼的疗效。

方法

这是一项对33例儿童青光眼患者的40只眼进行的回顾性比较研究:17只眼接受小梁切除术,23只眼接受小梁切开联合小梁切除术。两组均在术中使用丝裂霉素C。成功定义为眼压(IOP)≤21 mmHg且>5 mmHg,无需额外的青光眼手术。

结果

平均随访38.3个月。随访期间两组间平均眼压降低无显著差异。对数秩生存分析显示,与小梁切除术相比,联合手术的成功率显著更高(P = 0.027)。小梁切除术组有5例治疗失败,小梁切开联合小梁切除术组有2例治疗失败。失败原因是眼压升高(n = 3)或低眼压(n = 4)。两组术后观察到的并发症无显著差异。

结论

小梁切除术和丝裂霉素C小梁切开联合小梁切除术在降低儿童平均眼压方面同样有效。小梁切开联合小梁切除术的长期成功率更高。

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