Nadkarni Redha B, Fristad Mary A
Behavioral Health Services, Nationwide Children's Hospital, Columbus, Ohio, U.S.A.
Isr J Psychiatry Relat Sci. 2012;49(2):104-10.
This article reviews stress related to parenting a youth with bipolar disorder (BD), maladaptive coping, immunologic and physical functioning related to chronic stress; presents preliminary findings about the association between immune parameters and health conditions, mental health indices and interpersonal functioning in parents of children with mood disorders; and provides recommendations for stress management based on clinical trials of family-based psychoeducational psychotherapy (PEP).
Interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-reactive protein (CRP), Epstein Barr Virus (EBV), nutritional markers and measures of physical health, mental health and interpersonal functioning were collected from 26 parents of mood disordered children. Higher CRP was associated with more perceived stress, more depression, increased incidence of illness/ physical conditions, and lower albumin levels. Elevated IL-6 was associated with higher nicotine use.
Sample size and demographics were restricted, limiting generalizability.
Pilot data are consistent with literature from adult caregivers, and suggest caregivers who are more stressed also evidence some signs of immune abnormality. Evidence-based strategies to support parents are discussed.
本文回顾了养育双相情感障碍(BD)青少年所带来的压力、适应不良的应对方式、与慢性压力相关的免疫和身体功能;介绍了关于免疫参数与情绪障碍儿童家长的健康状况、心理健康指标及人际功能之间关联的初步研究结果;并基于家庭心理教育心理治疗(PEP)的临床试验提出压力管理建议。
从26名情绪障碍儿童的家长处收集了白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、C反应蛋白(CRP)、爱泼斯坦-巴尔病毒(EBV)、营养指标以及身体健康、心理健康和人际功能的测量数据。较高的CRP与更多的感知压力、更多的抑郁、疾病/身体状况发生率增加以及较低的白蛋白水平相关。IL-6升高与更高的尼古丁使用量相关。
样本量和人口统计学特征有限,限制了研究结果的普遍性。
初步数据与成年照料者的文献一致,表明压力更大的照料者也存在一些免疫异常的迹象。文中讨论了支持家长的循证策略。