Laboratory of Physiology, Medical School, University of Ioannina, Ioannina, Greece.
Hormones (Athens). 2012 Apr-Jun;11(2):178-88. doi: 10.14310/horm.2002.1345.
The investigation of the relationship between high density lipoprotein (HDL) and adiponectin.
Thirty-seven obese or overweight [body mass index ≥27 Kg/m(2)], hypertriglyceridemic patients underwent one of the following interventions for 3 months: 1) Low-calorie diet (n=19), 2) Low-calorie diet plus fenofibrate (n=18).
Circulating total adiponectin did not change significantly in the low-calorie diet group. However, in the subgroup of patients whose high density lipoprotein cholesterol (HDL-C) decreased over the first month of diet, a statistically significant reduction of the circulating total adiponectin was observed (p=0.010), while in the subgroup of patients whose HDL-C increased over the latter 2 months of the diet, an increase in circulating total adiponectin over the 2 months was found (p=0.043). The percentage change of HDL-C over the first month of diet was positively correlated with the percentage change of circulating total adiponectin (r=0.579, p=0.019). The percentage change of HDL-C over the 3 months of diet was positively correlated with the percentage changes of circulating total adiponectin (r=0.527, p=0.030) and high molecular weight (HMW) adiponectin (r=0.524, p=0.031). The change in circulating total adiponectin over the first month of diet was positively correlated with the HDL-C at 1 month (r=0.606, p=0.013). The change in HMW adiponectin over the 3 months of diet was positively correlated with the HDL-C at 3 months (r=0.602, p=0.011). The percentage change of circulating HMW adiponectin over the first month of fenofibrate treatment was positively correlated with the percentage change of HDL-C (r=0.594, p=0.012).
HDL is positively correlated with the changes in circulating adiponectin during dietary and fenofibrate treatment.
研究高密度脂蛋白（HDL）与脂联素之间的关系。
37 名肥胖或超重[体重指数（BMI）≥27kg/m2]、高三酰甘油血症患者接受以下干预措施之一，持续 3 个月：1）低热量饮食（n=19），2）低热量饮食加非诺贝特（n=18）。
低热量饮食组循环总脂联素无明显变化。然而，在第一个月饮食过程中高密度脂蛋白胆固醇（HDL-C）降低的亚组患者中，观察到循环总脂联素的统计学显著降低（p=0.010），而在 HDL-C 在后 2 个月增加的亚组患者中，发现循环总脂联素在这 2 个月中增加（p=0.043）。第一个月饮食期间 HDL-C 的百分比变化与循环总脂联素的百分比变化呈正相关（r=0.579，p=0.019）。3 个月饮食期间 HDL-C 的百分比变化与循环总脂联素（r=0.527，p=0.030）和高分子量（HMW）脂联素（r=0.524，p=0.031）的百分比变化呈正相关。第一个月饮食期间循环总脂联素的变化与第一个月的 HDL-C 呈正相关（r=0.606，p=0.013）。3 个月饮食期间 HMW 脂联素的变化与第三个月的 HDL-C 呈正相关（r=0.602，p=0.011）。非诺贝特治疗第一个月循环 HMW 脂联素的百分比变化与 HDL-C 的百分比变化呈正相关（r=0.594，p=0.012）。
HDL 与饮食和非诺贝特治疗期间循环脂联素的变化呈正相关。
