Mohammedsaeed Walaa, Ahmed Ahmed, Alharbi Nada, Aljohani Amjaad, Alruwaithi Razan, Alharbi Reem, Alahmadi Shatha
Department of Medical Laboratory Technology, Faculty of Applied Medical Science, Taibah University, Madinah, SAU.
Cureus. 2023 Aug 27;15(8):e44219. doi: 10.7759/cureus.44219. eCollection 2023 Aug.
Metabolic syndrome" (MetS) is a set of abnormalities that may be risk factors for cardiovascular disease (CVD) and diabetes. The current study sought to (1) determine MetS prevalence and (2) examine Adiponectin and ANGPTL8 levels in connection to MetS components and CVDs and diabetes risk in females with MetS.
A total of 350, 20-35-year-old Saudi females were studied. Waist circumference (WC), body mass index (BMI), glucose, HbA1c, insulin, lipid profiles, and blood pressure (BP) were examined for MetS. ANGPTL8 and Adiponectin were also measured.
The patients were classified into two groups, namely MetS and non-MetS, according to the criteria established by the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATPIII). We examined biomarker and anthropometric results between these groups. One hundred forty-four of 350 female participants (41.2%) had MetS, with a mean age of 30.5 years. Fasting blood glucose (FBG), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), ANGPTL8, adiponectin, and insulin resistance (IR) were statistically significant differences observed between the two groups. BP, BMI, WC, and Atherogenic Index of Plasma (AIP) all changed significantly (P ≤0.05). Correlation studies linked MetS components to higher ANGPTL-8 and reduced adiponectin. The levels of ANGPTL8 were shown to be influenced by the increase in FBG, TG, BP, IR, and AIP (P < 0.05). Factors such as FBG, BMI, WC, and IR have been found to have an inverse relationship with adiponectin levels.
41.2% out of 350 Saudi females at Taibah University in the Madinah region had MetS, medium CVD risk, and slightly elevated BMI, TG, WC, and BP. To lower their risk of CVD and diabetes later in life, overweight young women should be evaluated for MetS. FBG and TG were substantially associated with ANGPTL8 while reducing adiponectin was associated with elevated TG and BP. Our findings may lead to ANGPTL8 and adiponectin's possible predictive function for CVD in early MetS in females.
“代谢综合征”（MetS）是一组异常情况，可能是心血管疾病（CVD）和糖尿病的危险因素。本研究旨在（1）确定代谢综合征的患病率，以及（2）研究脂联素和血管生成素样蛋白8（ANGPTL8）水平与代谢综合征各组分、患有代谢综合征女性的心血管疾病及糖尿病风险之间的关系。
共对350名年龄在20至35岁之间的沙特女性进行了研究。检测了腰围（WC）、体重指数（BMI）、血糖、糖化血红蛋白（HbA1c）、胰岛素、血脂谱和血压（BP）以评估代谢综合征。同时也检测了ANGPTL8和脂联素。
根据美国国家胆固醇教育计划成人治疗小组第三次报告（NCEP-ATPIII）制定的标准，将患者分为两组，即代谢综合征组和非代谢综合征组。我们比较了两组之间的生物标志物和人体测量结果。350名女性参与者中有144名（41.2%）患有代谢综合征，平均年龄为30.5岁。两组之间在空腹血糖（FBG）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、ANGPTL8、脂联素和胰岛素抵抗（IR）方面存在统计学显著差异。血压（BP）、体重指数（BMI）、腰围（WC）和血浆致动脉粥样硬化指数（AIP）均有显著变化（P≤0.05）。相关性研究表明，代谢综合征各组分与较高的ANGPTL-8水平及降低的脂联素水平相关。ANGPTL8水平受空腹血糖（FBG）、甘油三酯（TG）、血压（BP）、胰岛素抵抗（IR）和血浆致动脉粥样硬化指数（AIP）升高的影响（P<0.05）。已发现空腹血糖（FBG）、体重指数（BMI）、腰围（WC）和胰岛素抵抗（IR）等因素与脂联素水平呈负相关。
麦地那地区泰巴大学的350名沙特女性中，41.2%患有代谢综合征，心血管疾病风险中等，体重指数（BMI）、甘油三酯（TG）、腰围（WC）和血压略有升高。为降低超重年轻女性日后患心血管疾病和糖尿病的风险，应评估她们是否患有代谢综合征。空腹血糖（FBG）和甘油三酯（TG）与ANGPTL8显著相关，而脂联素降低与甘油三酯（TG）和血压升高相关。我们的研究结果可能揭示ANGPTL8和脂联素在女性早期代谢综合征中对心血管疾病的潜在预测作用。
