Lester S, Rischmueller M, Tan Lw, Wormald Pj, Zalewski P, Hamilton-Bruce Ma, Appleton S, Adams Rj, Hill Cl
Centre for Inflammatory Disease Research (CIDR), The Basil Hetzel Institute for Translational Health Research, Woodville South, SA, Australia.
Open Rheumatol J. 2012;6:170-4. doi: 10.2174/1874312901206010170. Epub 2012 Jun 28.
To determine associations between sicca symptoms, chronic rhinosinusitis (CRS) symptoms and asthma in a community survey.
Data was obtained from the Spring 2009 South Australian Health Omnibus Survey which sampled, via interviewer administered questionnaire, 3007 individuals aged 15 years and over whose socio-demographic distribution corresponded to South Australian population estimates. Respondents were asked a range of questions relating to the presence of persistent dry eyes or dry mouth, CRS and medically diagnosed nasal polyps and asthma. Relationships between symptoms were explored using maximum likelihood dependency tree analysis.
THE RESPECTIVE POPULATION PREVALENCES WERE: dry mouth (5.9%), dry eyes (8.6%), nasal polyps (3.8%), CRS (13.2%) and asthma (12.0%). The overall prevalence of sicca symptoms (dry eyes or dry mouth) was 12.4%. Dependency tree analysis revealed the expected symptom clustering between (1) sicca symptoms and their association with female gender and increasing age and (2) CRS, nasal polyps and asthma (one airway hypothesis). However there was also an association between dry eyes and CRS (OR 2.5, 95% CI 1.9, 3.4), which was in fact stronger than the association between CRS and asthma (OR 1.9, 95% CI 1.4, 2.5).
Sicca symptoms are common in the community. Our novel finding of a strong association between dry eyes and CRS suggests that further research into the relationship between airway inflammation and sicca symptoms is required. These findings may have particular relevance to Sjögren's syndrome (SS) in both its primary and secondary forms.
在一项社区调查中确定干燥症状、慢性鼻窦炎（CRS）症状与哮喘之间的关联。
数据取自2009年春季南澳大利亚综合健康调查，通过访员管理的问卷对3007名15岁及以上的个体进行抽样，这些个体的社会人口学分布与南澳大利亚人口估计数相符。受访者被问及一系列关于持续性干眼或口干、CRS、医学诊断的鼻息肉和哮喘的问题。使用最大似然依赖树分析来探究症状之间的关系。
各自的人群患病率分别为：口干（5.9%）、干眼（8.6%）、鼻息肉（3.8%）、CRS（13.2%）和哮喘（12.0%）。干燥症状（干眼或口干）的总体患病率为12.4%。依赖树分析揭示了预期的症状聚类，即（1）干燥症状及其与女性性别和年龄增长的关联，以及（2）CRS、鼻息肉和哮喘（同一气道假说）。然而，干眼与CRS之间也存在关联（比值比2.5，95%可信区间1.9，3.4），实际上这一关联比CRS与哮喘之间的关联更强（比值比1.9，95%可信区间1.4，2.5）。
干燥症状在社区中很常见。我们关于干眼与CRS之间存在强关联的新发现表明，需要进一步研究气道炎症与干燥症状之间的关系。这些发现可能与原发性和继发性干燥综合征（SS）特别相关。
