Imperial College, Respiratory Epidemiology and Public Health Group and MRC-HPA Centre for Environment and Health, London, UK.
Allergy. 2012 Jan;67(1):91-8. doi: 10.1111/j.1398-9995.2011.02709.x. Epub 2011 Nov 4.
The prevalence of asthma and its association with chronic rhinosinusitis (CRS) have not been widely studied in population-based epidemiological surveys.
The Global Allergy and Asthma Network of Excellence (GA(2) LEN) conducted a postal questionnaire in representative samples of adults living in Europe to assess the presence of asthma and CRS defined by the European Position Paper on Rhinosinusitis and Nasal Polyps. The prevalence of self-reported current asthma by age group was determined. The association of asthma with CRS in each participating centre was assessed using logistic regression analyses, controlling for age, sex and smoking, and the effect estimates were combined using standard methods of meta-analysis.
Over 52,000 adults aged 18-75 years and living in 19 centres in 12 countries took part. In most centres, and overall, the reported prevalence of asthma was lower in older adults (adjusted OR for 65-74 years compared with 15-24 years: 0.72; 95% CI: 0.63-0.81). In all centres, there was a strong association of asthma with CRS (adjusted OR: 3.47; 95% CI: 3.20-3.76) at all ages. The association with asthma was stronger in those reporting both CRS and allergic rhinitis (adjusted OR: 11.85; 95% CI: 10.57-13.17). CRS in the absence of nasal allergies was positively associated with late-onset asthma.
Geographical variation in the prevalence of self-reported asthma was observed across Europe, but overall, self-reported asthma was more common in young adults, women and smokers. In all age groups, men and women, and irrespective of smoking behaviour, asthma was also associated with CRS.
哮喘的流行及其与慢性鼻-鼻窦炎（CRS）的关系尚未在基于人群的流行病学调查中广泛研究。
全球过敏和哮喘网络卓越中心（GA[2]LEN）在欧洲居住的成年人代表性样本中进行了邮寄问卷调查，以评估哮喘和欧洲鼻-鼻窦炎和鼻息肉意见书定义的 CRS 的存在。按年龄组确定自我报告的当前哮喘患病率。使用逻辑回归分析评估每个参与中心的哮喘与 CRS 的关联，控制年龄、性别和吸烟，使用荟萃分析的标准方法合并效应估计值。
超过 52000 名年龄在 18-75 岁之间、居住在 12 个国家的 19 个中心的成年人参加了这项研究。在大多数中心和总体上，老年成年人的报告哮喘患病率较低（65-74 岁与 15-24 岁相比的调整后比值比：0.72；95%可信区间：0.63-0.81）。在所有中心，哮喘与 CRS 之间存在强烈关联（调整后的比值比：3.47；95%可信区间：3.20-3.76），在所有年龄段均如此。在报告同时患有 CRS 和过敏性鼻炎的患者中，这种关联更强（调整后的比值比：11.85；95%可信区间：10.57-13.17）。没有鼻过敏的 CRS 与迟发性哮喘呈正相关。
在整个欧洲，观察到自我报告哮喘的流行存在地域差异，但总体而言，年轻成年人、女性和吸烟者的自我报告哮喘更为常见。在所有年龄组、男性和女性中，无论吸烟行为如何，哮喘也与 CRS 相关。
